Regioselective formation of the quinazoline moiety on the upper rim of calix[4]arene as a route to inherently chiral systems

N-acyl aminocalix[4]arenes were cyclized with nitriles to afford the expected quinazolines only in the case of para-substituted series. This strategy represents a new route to inherently chiral calixarenes potentially useful as fluorescent receptors.

Synthesis of inherently chiral calixarenes via direct mercuration of the partial cone conformation

Regioselective mercuration of calix[4]arene in the partial cone conformation enabled a straightforward access to a novel type of inherently chiral calixarenes with a highly distorted cavity.