This review summarizes the synthesis, reactions, and biological activities of
tetrazolo[1,5-a]quinoline derivatives. These derivatives were synthesized by several
methods such as i) from the reaction of 2-chloroquinoline with sodium azide ii) from diazotization
2-hydrazinylquinoline derivatives, and iii) from intramolecular cyclocondensation
of 2-azidoarylidenes. Also, the chemical reactions and pharmacological activities
of some tetrazoloquinolines such as tetrazolo[1,5-a]quinoline-4-carbaldehyde, 5-chlorotetrazolo[
1,5-a]quinoline, 4-(chloromethyl)tetrazolo[1,5-a]quinoline, tetrazolo[1,5-
a]quinoline-4-carboxylic acid, and 5-azidotetrazolo[1,5-a]quinoline were discussed.