Cost of tuberculosis-related aeromedical retrievals in the Torres Strait, Australia

Tuberculosis (TB) remains a disease of public health significance at the Australia / Papua New Guinea (PNG) international border. In the remote Torres Strait Islands, aeromedical evacuation is a necessary but costly component of TB management and patients with critical care needs require support to prevent onward TB transmission. A detailed costing of an exemplar TB patient from PNG who presented to a Queensland Health facility in the Torres Strait and required urgent aeromedical evacuation was performed. Data were drawn from patient charts, financial and clinical information systems used within Queensland Health and the Torres and Cape Hospital and Health Service. The total cost of aeromedical evacuation was AUD 124,280; 54% of the cost was attributed to travel. Between 2016 and 2019, 19 patients diagnosed with TB were medically evacuated from an outer Torres Strait Island with a median length of hospital stay of 57 days. Aeromedical evacuation and medical management costs require adequate budget allocation.

Non-Antibiotics Strategies to Control Salmonella Infection in Poultry

Salmonella spp. is a facultative intracellular pathogen causing localized or systemic infections, involving economic and public health significance, and remains the leading pathogen of food safety concern worldwide, with poultry being the primary transmission vector. Antibiotics have been the main strategy for Salmonella control for many years, which has allowed producers to improve the growth and health of food-producing animals. However, the utilization of antibiotics has been reconsidered since bacterial pathogens have established and shared a variety of antibiotic resistance mechanisms that can quickly increase within microbial communities. The use of alternatives to antibiotics has been recommended and successfully applied in many countries, leading to the core aim of this review, focused on (1) describing the importance of Salmonella infection in poultry and the effects associated with the use of antibiotics for disease control; (2) discussing the use of feeding-based (prebiotics, probiotics, bacterial subproducts, phytobiotics) and non-feeding-based (bacteriophages, in ovo injection, vaccines) strategies in poultry production for Salmonella control; and (3) exploring the use of complementary strategies, highlighting those based on -omics tools, to assess the effects of using the available antibiotic-free alternatives and their role in lowering dependency on the existing antimicrobial substances to manage bacterial infections in poultry effectively.

Biology, Epidemiology, and Public Health Significance of Malaria Disease Linked to Climate Changes

Malaria is a mosquito-borne infectious disease caused by obligate intraerythrocytic protozoa of the genus Plasmodium. As one of the most devastating global health issues, malaria is a sensitive disease to weather and climate conditions, in such a way the ongoing trends of increasing temperature and more variable weather could lead to malaria transmission spreading. Spatial and temporal variations in precipitation, temperature, and humidity that are projected to take place under different climate change scenarios will impact the biology and ecology of malaria vectors and subsequently the risk of disease transmission. Here, the authors review how climate and climate change may impact malaria transmission. They contrast ecological and behavioral characteristics of malaria vectors and parasites and how weather, climate, climate change, and socioeconomic factors may have very different impacts on their spatiotemporal occurrence and abundance and the resulting malaria risk.

Molecular Survey of Viral Poultry Diseases with an Indirect Public Health Significance in Central Ethiopia

The importance of poultry production is globally increasing, in Ethiopia as well, where high-quality protein and contained costs make poultry a valuable food resource. However, this entails some problems linked to rural, backyard and intensively reared flock proximity and pathogen circulation. This study is aimed at monitoring the presence of important viral pathogens in poultry (infectious bronchitis virus (IBV), avian metapneumovirus (aMPV), infectious bursal disease virus (IBDV) and Newcastle disease virus (NDV)) in Ethiopia. Respiratory and cloacal swabs and bursa of Fabricius and kidney imprints on FTA cards were collected in 2021 from 16 farms and tested for IBV, aMPV, NDV and IBDV. One farm was positive for IBDV, resulting in strains similar to those present in vaccines, belonging to genogroup A1a; two farms were positive for IBV but, due to sensitivity limits, only one sample was sequenced, resulting in a 4/91-like strain (GI-13); a layer farm tested positive for NDV with a Lasota-like vaccine strain. These findings suggest a low presence of these pathogens, probably due to the implementation of vaccination strategies, which is also testified by the detection of vaccine strains. A close diagnostic activity should be implemented on a routine basis in order to monitor pathogen circulation, ameliorate biosecurity measures and protect animal health and production levels.

Blastocystosis And Iron Deficiency Anemia in Pregnant Women. A Call to Deep in A Little-Known Association

During the last twenty-five years, in parallel with the demonstration of a rapid increase of the global prevalence of blastocystosis, it has been documented the association between this parasitic infection and iron deficiency anemia in general population. More recently, it has been evidenced the high prevalence of blastocystosis in pregnant women and its association with iron deficiency anemia. Herein, we revise the most recent progress in the understanding of this association, the possible mechanisms that support it, including the Blastocystis subtypes involved, and its clinical consequences and public health significance. Taken in consideration the adverse impacts of anemia on the health of mothers and progeny, an adequate prevention and control of this parasitism during pregnancy may be mandatory. At the same time, and looking the problem from a more holistic multi-diseasebased perspective, the current initiatives to improve the prevention and control of intestinal parasitism in endemic areas may include in their communication strategies actions to inform, both at academic and community levels, about the possible adverse effects of blastocystosis on pregnancy evolution.

An Observational Study of the Morning and Evening Behavior of Individuals With and Without Attention-Deficit/Hyperactivity Disorder

As individuals with ADHD move to young adulthood, the morning and evening times become of increased importance. Sixty individuals were enrolled in a 14-day study (30 with ADHD and 30 did not have ADHD). Participants provided self-reports of ADHD symptoms and impairment using ecological momentary assessments administered each morning and each evening. Participants also identified a collateral who could provide daily ratings of the participant during the same time. Driving data were also passively collected. Results indicated differences in self and collateral ratings of ADHD symptoms and impairment, with greater symptom endorsement and reports of impairment for the individuals with ADHD. Self-report indicated greater endorsement in the evening, relative to the morning, for individuals with ADHD. Collateral report did not interact with time of day. Passive evaluation of driving performance was not significantly different. Results indicate young adult ADHD symptoms and impairment can be reliably assessed in the morning/evening. Public Health Significance Evidence of ADHD symptoms and impairments were documented in the morning and evening hours for individuals diagnosed with ADHD. These results illustrate additional areas in need of attention in the refinement of treatments for adults with ADHD.

Occurrence of methicillin-resistant staphylococci in the pig-production chain in Ibadan, Nigeria

Staphylococcus species colonises humans and animals and is a major food contaminant with public health significance. Here, we assessed the occurrence of methicillin-resistant staphylococci (MRS) in the pig-production chain in Ibadan, Nigeria. Nares of 120 pigs and 10 farmers were sampled with sterile swabs whilst 54 pork samples were collected from a retail slaughterhouse. Staphylococcus species were isolated using enrichment, cefoxitin–aztreonam selective broth and Mannitol salt agar. Isolates were tested for susceptibility to cefoxitin (30 μg), oxacillin (1 μg) and vancomycin (30 μg). Methicillin-resistant staphylococci isolates were characterised using conventional biochemical tests. From 184 samples, 364 staphylococcal isolates were obtained. Amongst the 54 pork samples, 44.0% were contaminated with Staphylococcus species. Overall, 9 (2.5%) MRS were obtained and presumptively identified as Staphylococcus xylosus (n = 3), Staphylococcus sciuri (n = 3), Staphylococcus warneri (n = 2) and Staphylococcus cohnii (n = 1). There was no relationship between the prevalence of MRS between pigs and pig handlers in the farms, but Farm 2 had the highest frequency of 66.7% (p 0.05). Piglets had the highest prevalence of 66.7% (p 0.05) whilst MRS was absent in workers and pork samples. This study raises concerns about the cross-contamination of staphylococci in the food chain. Constant surveillance is imperative to ensure food safety.

Dominance of Zoonotic Pathogen Cryptosporidium Meleagridis in Broiler Chickens in Guangdong, China, Reveals Evidence of Cross-Transmission

Background Cryptosporidium is one of the most prevalent parasites infecting both birds and mammals. To examine the prevalence of Cryptosporidium species and evaluate the public health significance of domestic chickens in Guangdong Province, Southern China, we analyzed 1001 fecal samples collected from 43 intensive broiler chicken farms from six distinct geographical regions between June 2020 and March 2021. Methods Individual DNAs were subjected to nested PCR-based amplification and sequencing of the small subunit of the nuclear ribosomal RNA gene (SSU rRNA). The 60 kDa glycoprotein gene (pgp60) was performed from all positive SSU rRNA samples to characterise subtypes of C. meleagridis. Results Cryptosporidium infection rates was found to be 13.2%, comprising with infections with C. meleagridis (78/1001, 7.8%), C. baileyi (48/1001, 4.8%) and mixed infections (6/1001, 0.6%). Three subtype families were identified, IIIb, IIIe and IIIg. Six subtypes were identified in broiler chickens, including one novel (IIIgA25G3R1a) and five previously reported (IIIbA23G1R1c, IIIbA24G1R1, IIIbA21G1R1a, IIIeA17G2R1 and IIIeA26G2R1). Within these subtypes, five known subtypes were genetically identical to those identified in humans. Conclusions This is the first report of C. meleagridis in chickens from Guangdong. The frequent occurrence of C. meleagridis in domestic chickens and the common C. meleagridis subtypes identified both in humans and chickens is of public health significance. Our study indicates that broiler chickens represent a potential zoonotic risk for the transmission of Cryptosporidium in this region.