scholarly journals A comprehensive dosimetric study of Monte Carlo and pencil-beam algorithms on intensity-modulated proton therapy for breast cancer

2018 ◽  
Vol 20 (1) ◽  
pp. 128-136 ◽  
Author(s):  
Xiaoying Liang ◽  
Zuofeng Li ◽  
Dandan Zheng ◽  
Julie A. Bradley ◽  
Michael Rutenberg ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Monte Carlo ◽  
Proton Therapy ◽  
Pencil Beam ◽  
Intensity Modulated Proton Therapy ◽  
Intensity Modulated ◽  
Dosimetric Study

PO-1959 Intensity modulated proton therapy plans for left-sided breast cancer patients with pectus excavatum

2021 ◽  
Vol 161 ◽  
pp. S1667-S1668
Author(s):  
A. Gullhaug ◽  
D. Høynes ◽  
V. Vingelsgård ◽  
D. Tor-Ove ◽  
J. Senum ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Patients ◽  
Proton Therapy ◽  
Pectus Excavatum ◽  
Breast Cancer Patients ◽  
Intensity Modulated Proton Therapy ◽  
Intensity Modulated

Prospectively registered acute toxicity in breast cancer patients undergoing adjuvant intensity modulated proton therapy

2020 ◽  
Vol 138 ◽  
pp. S85
Author(s):  
K. Verhoeven ◽  
T. Opbroek ◽  
G. Vilches-Freixas ◽  
K. Limpens ◽  
J. Mannens ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Acute Toxicity ◽  
Cancer Patients ◽  
Proton Therapy ◽  
Breast Cancer Patients ◽  
Intensity Modulated Proton Therapy ◽  
Intensity Modulated

scholarly journals Dosimetric consequences of image guidance techniques on robust optimized intensity-modulated proton therapy for treatment of breast Cancer

2020 ◽  
Vol 15 (1) ◽  
Author(s):  
Xiaoying Liang ◽  
Raymond B. Mailhot Vega ◽  
Zuofeng Li ◽  
Dandan Zheng ◽  
Nancy Mendenhall ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Proton Therapy ◽  
Image Guidance ◽  
Intensity Modulated Proton Therapy ◽  
Intensity Modulated

Technical Note: Integrating an open source Monte Carlo code “MCsquare” for clinical use in intensity‐modulated proton therapy

2020 ◽  
Vol 47 (6) ◽  
pp. 2558-2574 ◽  
Author(s):  
Wei Deng ◽  
James E. Younkin ◽  
Kevin Souris ◽  
Sheng Huang ◽  
Kurt Augustine ◽  
...  
Keyword(s):  
Monte Carlo ◽  
Open Source ◽  
Proton Therapy ◽  
Technical Note ◽  
Monte Carlo Code ◽  
Clinical Use ◽  
Intensity Modulated Proton Therapy ◽  
Intensity Modulated

scholarly journals Feasibility study: Spot-scanning Proton Arc therapy (SPArc) for left-sided breast irradiation

2020 ◽  
Author(s):  
Sheng Chang ◽  
Gang Liu ◽  
Lewei Zhao ◽  
Joshua T Dilworth ◽  
Weili Zheng ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Proton Therapy ◽  
Normal Tissue ◽  
Breast Irradiation ◽  
Ipsilateral Lung ◽  
Intensity Modulated Proton Therapy ◽  
Intensity Modulated ◽  
Spot Scanning ◽  
Proton Treatment ◽  
Beam Delivery

Abstract Background This study investigated the feasibility and potential clinical benefit of utilizing a new proton treatment technique: Spot-scanning Proton Arc (SPArc) therapy for left-sided breast cancer irradiation to further reduce radiation dose to healthy tissue and mitigate the probability of normal tissue complications compared to conventional Intensity Modulated Proton Therapy(IMPT). Methods Eight patients diagnosed with left-sided breast cancer and treated with breast-preserving surgery followed by whole breast irradiation without regional nodal irradiation were included in this retrospective planning. Two proton treatment plans were generated for each patient: vertical intensity-modulated proton therapy used for clinical treatment (vIMPT, gantry angle 10°-30°) and SPArc for comparison purpose. Both SPArc and vIMPT plans were optimized using the robust optimization of ± 3.5% range and 5 mm setup uncertainties. Root-mean-square deviation dose (RMSD) volume histograms were used for plan robustness evaluation. All dosimetric results were evaluated based on dose-volume histograms (DVH), and the interplay effect was evaluated based on the accumulation of single-fraction 4D dynamic dose on CT50. The treatment beam delivery time was simulated based on a gantry rotation with energy-layer-switching-time (ELST) from 0.2 to 5 s. Results The average D1 to the heart and LAD were reduced to 53.63 cGy and 82.25 cGy compared with vIMPT 110.38 cGy (p = 0.001) and 170.38 cGy (p = 0.001), respectively. The average V5Gy and V20Gy of ipsilateral lung was reduced to 16.77% and 3.07% compared to vIMPT 25.56% (p = 0.001) and 4.68% (p = 0.003). Skin3mm mean and maximum dose was reduced to 3999.38 cGy and 4395.63 cGy compared to vIMPT 4104.25 cGy (p = 0.039) and 4411.63 cGy (p = 0.043), respectively. A significant relative risk reduction (RNTCP = NTCPSPArc / NTCPvIMPT) for organs at risk (OARs) was obtained with SPArc ranging from 0.61 to 0.86 depending on the clinical endpoint. The RMSD Volume Histogram(RVH) analysis shows SPArc provided better plan robustness in OARs sparing, including the heart, LAD, ipsilateral lung, and skin. The average estimated treatment beam delivery times were comparable to vIMPT plans when the ELST is about 0.5 s. Conclusion SPArc technique can further reduce dose delivered to OARs and the probability of normal tissue complications in patients treated for left-sided breast cancer.

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