Ligand-Free Reusable Palladium-Catalyzed Heck-Type Coupling Reactions of Hypervalent Iodine Reagents under Mild Conditions

2011 ◽  
Vol 353 (7) ◽  
pp. 1061-1066 ◽  
Author(s):  
Xiaoming Qu ◽  
Peng Sun ◽  
Tingyi Li ◽  
Jincheng Mao
Keyword(s):  
Hypervalent Iodine ◽  
Coupling Reactions ◽  
Mild Conditions ◽  
Ligand Free ◽  
Palladium Catalyzed ◽  
Type Coupling

Efficient symmetrical bidentate dioxime ligand-accelerated homogeneous palladium-catalyzed Suzuki–Miyaura coupling reactions of aryl chlorides

2017 ◽  
Vol 41 (1) ◽  
pp. 372-376 ◽  
Author(s):  
Jinyi Song ◽  
Hongyan Zhao ◽  
Yang Liu ◽  
Huatao Han ◽  
Zhuofei Li ◽  
...  
Keyword(s):  
High Activity ◽  
Cross Coupling ◽  
Coupling Reactions ◽  
Bidentate Ligands ◽  
Aryl Chlorides ◽  
Arylboronic Acids ◽  
Mild Conditions ◽  
Cross Coupling Reactions ◽  
Palladium Catalyzed

A series of N,O-bidentate ligands were synthesized and studied as high activity ligands for palladium-catalyzed Suzuki–Miyaura cross-coupling reactions of aryl chlorides with arylboronic acids under mild conditions.

Ligand-Free and Solvent-Free Synthesis of 1,3-Disubstituted Naphthalenes through Stille Coupling

Synlett ◽  
2020 ◽  
Vol 31 (09) ◽  
pp. 903-906
Author(s):  
Taoufik Rohand ◽  
Sanae Sbi ◽  
Victor Mkpenie ◽  
Kiyoshi Tanemura
Keyword(s):  
Functional Groups ◽  
Acetyl Chloride ◽  
Stille Coupling ◽  
Mechanistic Studies ◽  
Major Step ◽  
Mild Conditions ◽  
Synthetic Strategy ◽  
Ligand Free ◽  
Palladium Catalyzed ◽  
Solvent Free Synthesis

A variety of 1,3-disubstituted naphthalenes have been prepared by palladium-catalyzed annulation of (o-ethynylphenyl)acetyl chloride with design of a new synthetic strategy by Stille coupling using functionalized organostannanes. The method affords excellent yields of the substituted naphthalenes and accommodates a wide variety of functional groups under mild conditions. Mechanistic studies show intramolecular cyclization as a major step following C–C bond coupling.

Palladium‐Catalyzed Ligand‐Free C‐N Coupling Reactions: Selective Diheteroarylation of Amines with 2‐Halobenzimidazoles

2019 ◽  
Vol 15 (1) ◽  
pp. 129-135 ◽  
Author(s):  
Wei Sang ◽  
Ayao Jean Gavi ◽  
Bao‐Yi Yu ◽  
Hua Cheng ◽  
Ye Yuan ◽  
...  
Keyword(s):  
Coupling Reactions ◽  
Ligand Free ◽  
Palladium Catalyzed

One-pot Synthesis of Dibenzofurans via SNAr and Subsequent Ligand-free Palladium-catalyzed Intramolecular Aryl-aryl Cross-coupling Reactions under Microwave Irradiation

2011 ◽  
Vol 66 (8) ◽  
pp. 833-836
Author(s):  
Zhiping Che ◽  
Hui Xu
Keyword(s):  
Microwave Irradiation ◽  
Cross Coupling ◽  
Aryl Halides ◽  
Coupling Reactions ◽  
One Pot ◽  
One Pot Synthesis ◽  
Cross Coupling Reactions ◽  
Ligand Free ◽  
Palladium Catalyzed ◽  
Snar Reaction

An efficient one-pot synthesis of dibenzofurans, via SNAr reaction of aryl halides and ortho-bromophenols in the presence of anhydrous K2CO3 and subsequent ligand-free palladium-catalyzed intramolecular aryl-aryl cross-coupling cyclization under microwave irradiation, is described.

scholarly journals Palladium-catalyzed Sonogashira coupling reactions in γ-valerolactone-based ionic liquids

2019 ◽  
Vol 15 ◽  
pp. 2907-2913 ◽  
Author(s):  
László Orha ◽  
József M Tukacs ◽  
László Kollár ◽  
László T Mika
Keyword(s):  
Ionic Liquid ◽  
Ionic Liquids ◽  
Reaction Medium ◽  
Cross Coupling ◽  
Environmental Efficiency ◽  
Coupling Reactions ◽  
Sonogashira Coupling ◽  
Mild Conditions ◽  
Palladium Catalyzed ◽  
Alternative Reaction Medium

It was demonstrated that the γ-valerolactone-based ionic liquid, tetrabutylphosphonium 4-ethoxyvalerate as a partially bio-based solvent can be utilized as alternative reaction medium for copper- and auxiliary base-free Pd-catalyzed Sonogashira coupling reactions of aryl iodides and functionalized acetylenes under mild conditions. Twenty-two cross-coupling products were isolated with good to excellent yields (72–99%) and purity (>98%). These results represent an example which proves that biomass-derived safer solvents can be utilized efficiently in common, industrially important transformations exhibiting higher chemical and environmental efficiency.

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