Regioselective Hydroxylation of Stilbenes by Engineered Cytochrome P450 fromThermobifida fuscaYX

2017 ◽  
Vol 359 (6) ◽  
pp. 984-994 ◽  
Author(s):  
Ansgar Rühlmann ◽  
Dragutin Antovic ◽  
Thomas J. J. Müller ◽  
Vlada B. Urlacher
Keyword(s):  
Cytochrome P450 ◽  
Regioselective Hydroxylation

Regioselective Hydroxylation of C12-C15Fatty Acids with Fluorinated Substituents by Cytochrome P450 BM3

2013 ◽  
Vol 19 (41) ◽  
pp. 13680-13691 ◽  
Author(s):  
Chih-Hsiang Chiang ◽  
Ravirala Ramu ◽  
Yi-Jung Tu ◽  
Chung-Ling Yang ◽  
Kok Yaoh Ng ◽  
...  
Keyword(s):  
Cytochrome P450 ◽  
P450 Bm3 ◽  
Regioselective Hydroxylation ◽  
Cytochrome P450 Bm3

Contribution of human hepatic cytochrome P450 isoforms to regioselective hydroxylation of steroid hormones

Xenobiotica ◽  
1998 ◽  
Vol 28 (6) ◽  
pp. 539-547 ◽  
Author(s):  
T. NIWA ◽  
Y. YABUSAKI ◽  
K. HONMA ◽  
N. MATSUO ◽  
K. TATSUTA ◽  
...  
Keyword(s):  
Cytochrome P450 ◽  
Steroid Hormones ◽  
Cytochrome P450 Isoforms ◽  
Regioselective Hydroxylation ◽  
Hepatic Cytochrome

Molecular evolution of a cytochrome P450 for the synthesis of potential antidepressant (2R,6R)-hydroxynorketamine

2021 ◽  
Author(s):  
Ansgar Bokel ◽  
Michael C. Hutter ◽  
Vlada B. Urlacher
Keyword(s):  
Cytochrome P450 ◽  
Molecular Evolution ◽  
Cytochrome P450 Monooxygenase ◽  
P450 Monooxygenase ◽  
Effective Synthesis

Engineered cytochrome P450 monooxygenase CYP154E1 enables the effective synthesis of the potential antidepressant (2R,6R)-hydroxynorketamine via N-demethylation and regio- and stereoselective hydroxylation of (R)-ketamine.

Comparison of mechanism-based inhibition of human cytochrome P450 2C19 by ticlopidine, clopidogrel, and prasugrel

Xenobiotica ◽  
2009 ◽  
Vol 00 (00) ◽  
pp. 090901052457079-8
Author(s):  
Y. Nishiya ◽  
K. Hagihara ◽  
A. Kurihara ◽  
N. Okudaira ◽  
N.A. Farid ◽  
...  
Keyword(s):  
Cytochrome P450 ◽  
Human Cytochrome ◽  
Cytochrome P450 2C19

Deactivation of anti-cancer drug letrozole to a carbinol metabolite by polymorphic cytochrome P450 2A6 in human liver microsomes

Xenobiotica ◽  
2009 ◽  
Vol 00 (00) ◽  
pp. 090901052053001-8
Author(s):  
K. Murai ◽  
H. Yamazaki ◽  
K. Nakagawa ◽  
R. Kawai ◽  
T. Kamataki
Keyword(s):  
Cytochrome P450 ◽  
Human Liver ◽  
Liver Microsomes ◽  
Human Liver Microsomes ◽  
Cancer Drug ◽  
Anti Cancer ◽  
Cytochrome P450 2A6

Selegiline Metabolism and Cytochrome P450 Enzymes:In vitro Study in Human Liver Microsomes*

2000 ◽  
Vol 86 (5) ◽  
pp. 215-221 ◽  
Author(s):  
Paivi Taavitsainen ◽  
Markku Anttila ◽  
Leena Nyman ◽  
Hari Karnani ◽  
Jarmo S. Salonen ◽  
...  
Keyword(s):  
Cytochrome P450 ◽  
Human Liver ◽  
Liver Microsomes ◽  
Human Liver Microsomes ◽  
Vitro Study
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