scholarly journals Warfarin-associated multiple digital necrosis complicating heparin-induced thrombocytopenia and Raynaud's phenomenon after aortic valve replacement for adenocarcinoma-associated thrombotic endocarditis

2003 ◽  
Vol 75 (1) ◽  
pp. 56-62 ◽  
Author(s):  
Theodore E. Warkentin ◽  
Richard P. Whitlock ◽  
Kevin H.T. Teoh
Keyword(s):  
Aortic Valve ◽  
Aortic Valve Replacement ◽  
Valve Replacement ◽  
Raynaud’S Phenomenon ◽  
Raynaud's Phenomenon ◽  
Heparin Induced Thrombocytopenia ◽  
Digital Necrosis

scholarly journals Concurrent mechanical haemolytic anaemia and heparin-induced thrombocytopenia following transcatheter aortic valve replacement

2018 ◽  
pp. bcr-2017-224069
Author(s):  
Nathan W Furukawa ◽  
Fernando M Jumalon ◽  
Daniel B Friedman ◽  
Linda R Kelly
Keyword(s):  
Aortic Valve ◽  
Aortic Valve Replacement ◽  
Prothrombin Time ◽  
Valve Replacement ◽  
Haemolytic Anaemia ◽  
Transcatheter Aortic Valve Replacement ◽  
Severe Aortic Stenosis ◽  
Paravalvular Leak ◽  
Heparin Induced Thrombocytopenia ◽  
Transcatheter Aortic Valve

A 78-year-old man with a history of severe aortic stenosis presented with confusion, irregular behaviour and dyspnoea 8 days following transcatheter aortic valve replacement. His exam was consistent with a heart failure exacerbation and he had elevated aminotransferases, bilirubin and prothrombin time suggestive of shock liver. A CT head scan demonstrated a subacute large left temporoparietal infarction. His aminotransferase and prothrombin time levels normalised with diuresis, but his indirect bilirubin remained elevated and he developed anaemia and thrombocytopenia consistent with a haemolytic anaemia. A transthoracic echocardiogram demonstrated a paravalvular leak. His thrombocytopenia continued to worsen prompting testing for antibodies against heparin-PF4 complexes which was positive. A serotonin release assay later returned positive, confirming the diagnosis of heparin-induced thrombocytopenia. This case illustrates that the presence of haemolytic anaemia does not necessarily exclude other causes of thrombocytopenia that may occur concurrently.

scholarly journals Delayed-Onset Heparin-Induced Thrombocytopenia Following Aortic Valve Replacement

2018 ◽  
Vol 47 (3) ◽  
pp. 113-117
Author(s):  
Yasuo Kondo ◽  
Noriyuki Takashima ◽  
Tomoaki Suzuki ◽  
Tohru Asai
Keyword(s):  
Aortic Valve ◽  
Aortic Valve Replacement ◽  
Valve Replacement ◽  
Heparin Induced Thrombocytopenia ◽  
Delayed Onset
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