Aortic Valve
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2021 ◽  
Vol 16 (12) ◽  
pp. 3703-3707
Marcello Chiocchi ◽  
Francesca D'Errico ◽  
Vincenzo De Stasio ◽  
Federica Di Tosto ◽  
Luca Pugliese ◽  

2021 ◽  
Vol 159 ◽  
pp. 100-106
Sarah Hanigan ◽  
Xiaowen Kong ◽  
Brian Haymart ◽  
Eva Kline-Rogers ◽  
Scott Kaatz ◽  

2021 ◽  
Thomas Poschner ◽  
Paul Werner ◽  
Alfred Kocher ◽  
Guenther Laufer ◽  
Francesco Musumeci ◽  

Transcatheter aortic valve replacement is a valuable alternative technique to surgery and the spectrum of therapy continues to evolve. The JenaValve Pericaridal transcatheter aortic valve replacement System allows prosthesis fixation in a native, noncalcified aortic annulus with a unique paper clip-like anchorage mechanism. The low rate of paravalvular leakage and permanent pacemaker implantation emphasizes the further widespread use of the JenaValve – despite the limited data available. In May 2021, a CE mark for the transfemoral implantation in both aortic regurgitation and aortic stenosis was granted. However, no data have been published so far. The ongoing ALIGN trials are expected to provide the pending long-term data.

Tilman Emrich

Emily M. Nordquist ◽  
Punashi Dutta ◽  
Karthik M. Kodigepalli ◽  
Carol Mattern ◽  
Michael R. McDermott ◽  

Objective: Aortic valve disease is a common worldwide health burden with limited treatment options. Studies have shown that the valve endothelium is critical for structure-function relationships, and disease is associated with its dysfunction, damage, or injury. Therefore, therapeutic targets to maintain a healthy endothelium or repair damaged endothelial cells could hold promise. In this current study, we utilize a surgical mouse model of heart valve endothelial cell injury to study the short-term response to injury at molecular and cellular levels. The goal is to determine if the native heart valve exhibits a reparative response and identify the mechanisms underlying this process. Approach and Results: Mild aortic valve endothelial injury and abrogated function was evoked by inserting a guidewire down the carotid artery of young (3 months) and aging (16–18 months) wild-type mice. Short-term cellular responses were examined at 6 hours, 48 hours, and 4 weeks following injury, whereas molecular profiles were determined after 48 hours by RNA-sequencing. Within 48 hours following endothelial injury, young wild-type mice restore endothelial barrier function in association with increased cell proliferation, and upregulation of transforming growth factor beta 1 ( Tgfβ1 ) and the glycoprotein, collagen triple helix repeat containing 1 ( Cthrc1 ). Interestingly, this beneficial response to injury was not observed in aging mice with known underlying endothelial dysfunction. Conclusions: Data from this study suggests that the healthy valve has the capacity to respond to mild endothelial injury, which in short term has beneficial effects on restoring endothelial barrier function through acute activation of the Tgfβ1-Cthrc1 signaling axis and cell proliferation.

2021 ◽  
Robert Whiting ◽  
Elizabeth Sander ◽  
Claire Conway ◽  
Ted J Vaughan

The competing structural and hemodynamic considerations in valve design generally require a large amount of in vitro hydrodynamic and durability testing during development, often resulting in inefficient “trial-and-error” prototyping. While in silico modelling through Finite Element Analysis (FEA) has been widely used to inform valve design by optimizing structural performance, few studies have exploited the potential insight FEA could provide into critical hemodynamic performance characteristics of the valve. The objective of this study is to demonstrate the potential of FEA to predict the hydrodynamic performance of aortic valve implants obtained during development through in vitro testing. Several variations of surgical tri-leaflet aortic valves were de-signed and manufactured using a synthetic polymer and hydrodynamic testing carried out using a pulsatile flow rig according to ISO 5840, with bulk hydro-dynamic parameters measured. In silico models were developed in tandem and suitable surrogate measures were investigated as predictors of the hydro-dynamic parameters. Through regression analysis, the in silico parameters of leaflet coaptation area, geometric orifice area and opening pressure were found to be suitable indicators of experimental in vitro hydrodynamic param-eters: regurgitant fraction, effective orifice area and transvalvular pressure drop performance, respectively.

2021 ◽  
Vol 22 (20) ◽  
pp. 11081
Shintaro Katahira ◽  
Yukiharu Sugimura ◽  
Sophia Grupp ◽  
Robin Doepp ◽  
Jessica Isabel Selig ◽  

Background: We aimed to examine the anti-calcification and anti-inflammatory effects of pioglitazone as a PPAR-gamma agonist on bioprosthetic-valve-bearing aortic grafts in a rat model of diabetes mellitus (DM). Methods: DM was induced in male Wistar rats by high-fat diet with an intraperitoneal streptozotocin (STZ) injection. The experimental group received additional pioglitazone, and controls received normal chow without STZ (n = 20 each group). Cryopreserved aortic donor grafts including the aortic valve were analyzed after 4 weeks and 12 weeks in vivo for analysis of calcific bioprosthetic degeneration. Results: DM led to a significant media proliferation at 4 weeks. The additional administration of pioglitazone significantly increased circulating adiponectin levels and significantly reduced media thickness at 4 and 12 weeks, respectively (p = 0.0002 and p = 0.0107, respectively). Graft media calcification was highly significantly inhibited by pioglitazone after 12 weeks (p = 0.0079). Gene-expression analysis revealed a significant reduction in relevant chondro-osteogenic markers osteopontin and RUNX-2 by pioglitazone at 4 weeks. Conclusions: Under diabetic conditions, pioglitazone leads to elevated circulating levels of adiponectin and to an inhibition of bioprosthetic graft degeneration, including lower expression of chondro-osteogenic genes, decreased media proliferation, and inhibited graft calcification in a small-animal model of DM.

Gilberto J. Aquino ◽  
Josua A. Decker ◽  
U. Joseph Schoepf ◽  
Landin Carson ◽  
Namrata Paladugu ◽  

2021 ◽  
Vol 49 (7) ◽  
pp. 585-587
Emir Karacaglar ◽  
Arzu Neslihan Akgun ◽  
Alp Aydinalp ◽  
Deniz Sarp Beyazpinar ◽  

Herz ◽  
2021 ◽  
Ali Rıza Akyüz ◽  
Ali Hakan Konuş ◽  
Ömer Faruk Çırakoğlu ◽  
Sinan Şahin ◽  
Selim Kul ◽  

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