scholarly journals Successful treatment of deep vein thrombosis in homozygous protein C deficiency with activated protein C

1993 ◽  
Vol 44 (3) ◽  
pp. 218-219 ◽  
Author(s):  
Hideo Wada ◽  
Katsumi Deguch ◽  
Shigeru Shirakawa ◽  
Koji Suzuki
Keyword(s):  
Deep Vein Thrombosis ◽  
Successful Treatment ◽  
Protein C ◽  
Activated Protein C ◽  
Protein C Deficiency ◽  
Vein Thrombosis ◽  
Deep Vein

Protein C Antigen Levels in Major Abdominal Surgery: Relationships to Deep Vein Thrombosis, Malignancy and Treatment with Stanozolol

1985 ◽  
Vol 54 (03) ◽  
pp. 622-625 ◽  
Author(s):  
S L Blamey ◽  
G D O Lowe ◽  
R M Bertina ◽  
C Kluft ◽  
H M Sue-Ling ◽  
...  
Keyword(s):  
Deep Vein Thrombosis ◽  
Abdominal Surgery ◽  
Protein C ◽  
Potent Inhibitor ◽  
Activated Protein C ◽  
Preoperative Treatment ◽  
Protein C Deficiency ◽  
Vein Thrombosis ◽  
Recurrent Venous Thrombosis ◽  
Deep Vein

SummaryActivated protein C is a potent inhibitor of coagulation, and familial protein C deficiency has been associated with recurrent venous thrombosis. We have investigated protein C antigen levels in patients undergoing major elective abdominal surgery, to determine their relationships to postoperative deep vein thrombosis (DVT), malignancy, and preoperative treatment with intramuscular or oral stanozolol. Preoperative and postoperative protein C levels were not significantly different in patients with and without DVT (detected by 125I-fibrinogen leg scans), nor in patients with and without malignancy. In a placebo group (n = 26), a significant fall in protein C was maximal on the first postoperative day and persisted for 7 days. In a group given intramuscular stanozolol, 50 mg on the preoperative day (n = 23) stanozolol shortened the duration of the postoperative fall in protein C, but did not prevent DVT. In a group given oral stanozolol, 10 mg/day for 2 weeks before and 1 week after operation (n = 11), stanozolol significantly increased protein C levels prior to surgery, hence maintaining protein C at pretreatment levels after surgery. The effect of this regimen on the incidence of DVT is under study.

Patients with APC Resistance Compared with Those with Other Clotting Inhibitor Deficiencies Show Later Onset of Venous Thrombosis During Oral Contraception

1995 ◽  
Vol 1 (4) ◽  
pp. 274-276 ◽  
Author(s):  
Antonio Girolami ◽  
Paolo Simioni ◽  
Sandra Zanardi ◽  
Luigi Scarano ◽  
Bruno Girolami
Keyword(s):  
Deep Vein Thrombosis ◽  
Protein C ◽  
Antithrombin Iii ◽  
Activated Protein C ◽  
Protein S ◽  
Oral Contraception ◽  
Vein Thrombosis ◽  
Apc Resistance ◽  
At Iii ◽  
Deep Vein

The prevalence of deep vein thrombosis in female patients with antithrombin III (AT III), protein C, or protein S deficiency who are on oral contraception has been compared with that of patients with activated protein C (APC) resistance. In the latter case the prevalence was lower (36.4%) than in the AT III deficiency group (71.4%) but similar to that seen in the protein C and protein S group (25%).' Furthermore, venous thrombosis occurred with APC resistance much later than with AT III, protein C, or protein S defects. The time lag between onset of oral contraception and thrombosis (~16 cycles) was not statistically different from that seen in a group of women who were known to have no antithrombin III, protein C, or protein S defects. It appears that as far as the interaction with oral contraception is concerned APC resistance is a much less severe condition compared with other clotting inhibitor defects. Key Words: Oral contraceptive—Activated protein C resistance—Deep vein thrombosis.

Sensitivity to activated protein C in patients with deep vein thrombosis during early puerperium period

2005 ◽  
Vol 84 (8) ◽  
pp. 799-801 ◽  
Author(s):  
Ryota Ohashi ◽  
Motoi Sugimura ◽  
Takakazu Kawamura ◽  
Naoaki Tamura ◽  
Naohiro Kanayama
Keyword(s):  
Deep Vein Thrombosis ◽  
Protein C ◽  
Activated Protein C ◽  
Vein Thrombosis ◽  
Deep Vein

NORMAL PREGNANCY AND DELIVERY IN A PATIENT WITH SEVERE PROTEIN C DEFICIENCY AND PREVIOUS DEEP-VEIN THROMBOSIS

1987 ◽  
Author(s):  
H Bounameaux ◽  
Ph de Moerloose ◽  
J Vogel ◽  
G Reber ◽  
B Krahenbuhl ◽  
...  
Keyword(s):  
Deep Vein Thrombosis ◽  
Protein C ◽  
Venous Blood ◽  
Family Members ◽  
Activity Levels ◽  
Protein C Deficiency ◽  
Vein Thrombosis ◽  
Venous Thromboembolic Events ◽  
Pregnancy And Delivery ◽  
Deep Vein

Congenital protein C (PC) deficiency is associated with thrombophilia. Heterozygotes with about half-normal plasma PC levels may present with venous thromboembolic events usually beginning during adolescence or young adulthood. A 26-year-old swiss woman had experienced an iliofemoral deep-vein thrombosis without obvious etiology six years.ago. In June, 1986 very low levels of PC antigen (25 %) and activity (27 %) were found when she was six-month pregnant. Three other family members (62, 24 and 19-year-old) had PC levels around 50 % but were symptomfree. Because of the post-thrombotic~syndrome and the pregnancy, ambulatory heparin therapy was immediately started in the patient (10-16'000 IU twice daily, s.c.) in order to maintain a plasma heparin level between 0.2 and 0.5 U/ml six hs after the morning injection. Delivery was induced at full-term whilst heparin was stopped for a few hours. Four weeks after delivery anticoagulation was discontinued and, so far, the patient remained symptomfree. The newborn showed no perinatal problem and the PC antigen level assayed in the umbilical venous blood was 22 % (normal range in the literature 18-46 %). Antithrombin III and protein S levels as well as fibtinolytic potential were within normal values in all family members.Conclusions. 1) Only one out of four heterozygote PC deficient family members had presented with venous thromboembolism. 2) The symptomatic subject had the lowest PC level in the family (activity and antigen around 25 %). 3) This woman experienced an event-free pregnancy and delivery although heparin was started only in the sixth month of pregnancy. 4) Thus, penetrance of the thrombotic trait may be quite variable (and low) amongst PC deficient heterozygotes, an observation which raises the question of the indication of long-term anticoagulation in these individuals. 5) Pregnancy did not affect the PC antigen and activity levels in our patient.

The incidence of activated protein C resistance among patients with deep vein thrombosis and healthy subjects in Osaka

1995 ◽  
Vol 79 (2) ◽  
pp. 227-229 ◽  
Author(s):  
J. Kambayashi ◽  
H. Fujimura ◽  
T. Kawasaki ◽  
M. Sakon ◽  
M. Monden ◽  
...  
Keyword(s):  
Deep Vein Thrombosis ◽  
Healthy Subjects ◽  
Protein C ◽  
Activated Protein C ◽  
Activated Protein C Resistance ◽  
Vein Thrombosis ◽  
Deep Vein
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