Palladium-Catalyzed Decarboxylative Suzuki and Heck Couplings of Azaindole-2-carboxylic Acids: Synthesis of 2-Aryl/Alkenyl-1-phenylsulfonyl-1 H-pyrrolo-[2,3 b]pyridines

2013 ◽  
Vol 2 (2) ◽  
pp. 169-175 ◽  
Author(s):  
Rajendran Suresh ◽  
Shanmugam Muthusubramanian ◽  
Rajendran Senthil Kumaran ◽  
Govindaswamy Manickam
Keyword(s):  
Carboxylic Acids ◽  
Palladium Catalyzed

Ligand-Enabled γ-C(sp3)–H Olefination of Free Carboxylic Acids

2020 ◽  
Author(s):  
Kiron Kumar Ghosh ◽  
Alexander Uttry ◽  
Francesca Ghiringhelli ◽  
Arup Mondal ◽  
Manuel van Gemmeren
Keyword(s):  
Reaction Mechanism ◽  
Carboxylic Acids ◽  
Michael Addition ◽  
Kinetic Studies ◽  
Wide Range ◽  
Palladium Catalyzed

We report the ligand enabled C(sp3)–H activation/olefination of free carboxylic acids in the γ-position. Through an intramolecular Michael-addition, δ-lactones are obtained as products. Two distinct ligand classes are identified that enable the challenging palladium-catalyzed activation of free carboxylic acids in the γ-position. The developed protocol features a wide range of acid substrates and olefin reaction partners and is shown to be applicable on a preparatively useful scale. Insights into the underlying reaction mechanism obtained through kinetic studies are reported.<br>

ChemInform Abstract: “Ligand-Free” Palladium-Catalyzed Direct C-H Bond Oxidative Acyloxylation of 2-Arylpyridines with Aromatic Carboxylic Acids.

ChemInform ◽  
2012 ◽  
Vol 43 (35) ◽  
pp. no-no
Author(s):  
Chao-Jun Hu ◽  
Xiao-Hong Zhang ◽  
Qiu-Ping Ding ◽  
Ting Lv ◽  
Shao-Peng Ge ◽  
...  
Keyword(s):  
Carboxylic Acids ◽  
Aromatic Carboxylic Acids ◽  
Ligand Free ◽  
Palladium Catalyzed

ChemInform Abstract: Palladium-Catalyzed Oxidative C-O Cross-Coupling of Ketene Dithioacetals and Carboxylic Acids

ChemInform ◽  
2014 ◽  
Vol 45 (41) ◽  
pp. no-no
Author(s):  
Deqiang Liang ◽  
Mang Wang ◽  
Ying Dong ◽  
Yaru Guo ◽  
Qun Liu
Keyword(s):  
Carboxylic Acids ◽  
Cross Coupling ◽  
Ketene Dithioacetals ◽  
Palladium Catalyzed

ChemInform Abstract: Efficient Palladium-Catalyzed C-H Fluorination of C(sp3)-H Bonds: Synthesis of β-Fluorinated Carboxylic Acids.

ChemInform ◽  
2015 ◽  
Vol 46 (52) ◽  
pp. no-no
Author(s):  
Qihua Zhu ◽  
Dezhong Ji ◽  
Tingting Liang ◽  
Xueyan Wang ◽  
Yungen Xu
Keyword(s):  
Carboxylic Acids ◽  
Palladium Catalyzed
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