scholarly journals A critique of the drug discovery and phase 3 clinical programs targeting the amyloid hypothesis for Alzheimer disease

2014 ◽  
Vol 76 (2) ◽  
pp. 185-205 ◽  
Author(s):  
Eric Karran ◽  
John Hardy
Keyword(s):  
Drug Discovery ◽  
Alzheimer Disease ◽  
Phase 3 ◽  
Amyloid Hypothesis

scholarly journals EDITORIAL: FAILURE AFTER FAILURE. WHAT NEXT IN AD DRUG DEVELOPMENT?

2019 ◽  
pp. 1-1 ◽  
Author(s):  
P.S. Aisen
Keyword(s):  
Drug Development ◽  
Phase 3 ◽  
Efficacy Analysis ◽  
Amyloid Hypothesis ◽  
Disease Modifying ◽  
Disease Modifying Agents

The Phase 3 aducanumab program in early AD has been stopped based on a futility efficacy analysis. This huge disappointment follows exciting preliminary studies that had raised expectations (1). Now this frustrating result joins the long series of negative and interrupted trials of potential disease-modifying agents, going back to tarenflurbil (2), tramiprosate (3), and bapineuzumab (4), among many others. Is the amyloid hypothesis wrong? Where do we go from here?

scholarly journals Preclinical Alzheimer Disease Drug Development: Early Considerations Based on Phase 3 Clinical Trials

2020 ◽  
Vol 26 (7) ◽  
pp. 888-900
Author(s):  
Anna Hung ◽  
Monika Schneider ◽  
Marianne Hamilton Lopez ◽  
Mark McClellan
Keyword(s):  
Clinical Trials ◽  
Alzheimer Disease ◽  
Drug Development ◽  
Phase 3

The probabilistic model of Alzheimer disease: the amyloid hypothesis revised

2021 ◽  
Author(s):  
Giovanni B. Frisoni ◽  
Daniele Altomare ◽  
Dietmar Rudolf Thal ◽  
Federica Ribaldi ◽  
Rik van der Kant ◽  
...  
Keyword(s):  
Alzheimer Disease ◽  
Probabilistic Model ◽  
Amyloid Hypothesis

Barriers to Drug Discovery and Development for Alzheimer Disease

2002 ◽  
Vol 16 ◽  
pp. S1-S8 ◽  
Author(s):  
Howard M. Fillit ◽  
Alan W. O'Connell ◽  
William M. Brown ◽  
Larry D. Altstiel ◽  
Ravi Anand ◽  
...  
Keyword(s):  
Drug Discovery ◽  
Alzheimer Disease ◽  
Drug Discovery And Development

scholarly journals Barriers to Alzheimer Disease Drug Discovery and Development in Academia

2002 ◽  
Vol 16 ◽  
pp. S18-S28 ◽  
Author(s):  
Linda J. Van Eldik ◽  
Tanuja Koppal ◽  
D. Martin Watterson
Keyword(s):  
Drug Discovery ◽  
Alzheimer Disease ◽  
Drug Discovery And Development
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