Rhodium-Catalyzed Regioselective Carboacylation of Olefins: A CC Bond Activation Approach for Accessing Fused-Ring Systems

2012 ◽  
Vol 124 (30) ◽  
pp. 7685-7689 ◽  
Author(s):  
Tao Xu ◽  
Guangbin Dong
Keyword(s):  
Bond Activation ◽  
Ring Systems ◽  
Fused Ring

Synthesis of Pyrazolofuropyrazine via One-Pot SNAr Reaction and Intramolecular Direct C–H Arylation

Synthesis ◽  
2018 ◽  
Vol 50 (07) ◽  
pp. 1493-1498 ◽  
Author(s):  
Shinichiro Fuse ◽  
Hiroyuki Nakamura ◽  
Megumi Inaba ◽  
Shinichi Sato ◽  
Manjusha Joshi
Keyword(s):  
Drug Discovery ◽  
Rapid Development ◽  
Ring System ◽  
Biologically Active ◽  
Drug Candidate ◽  
One Pot ◽  
Ring Systems ◽  
Drug Candidates ◽  
Fused Ring ◽  
Snar Reaction

Fused-ring systems containing heterocycles are attractive templates for drug discovery. Biologically active 6-5-5+6 fused-ring systems that possess heterocycles are available, but these require a relatively large number of synthetic steps for preparation. Therefore, pyrazolofuropyrazine was designed as a 6-5-5+6 ring system template that incorporates ready accessibility for drug discovery. Pyrazolofuropyrazines were successfully constructed in only a few steps via one-pot SNAr reaction/intramolecular C–H direct arylation. As a drug candidate, pyrazolofuropyrazine has earned a favorable LogP, although significant biological activity has yet to be established; the ready accessibility of pyrazolofuropyrazine template, however, offers an opportunity for the rapid development of promising new drug candidates.

Synthesis of Fused Ring Systems with Ring Junction Heteroatoms

2010 ◽  
pp. 889-916
Author(s):  
Alan R. Katritzky ◽  
Christopher A. Ramsden ◽  
John A. Joule ◽  
Viktor V. Zhdankin
Keyword(s):  
Ring Systems ◽  
Ring Junction ◽  
Fused Ring

10.24.5 Product Subclass 5: Pyridazino[1,6-a]indoles and Related Benzo-Fused Ring Systems

2021 ◽  
Author(s):  
P. A. Harris
Keyword(s):  
Ring Systems ◽  
Fused Ring

AbstractThe synthesis of pyridazino[1,6-a]indoles, as well as the related indolo[1,2-b]cinnolines and indolo[2,1-a]phthalazines, are reviewed in this chapter. The most utilized methods to access pyridazino[1,6-a]indoles involve annulation of 1H-indol-1-amine derivatives.

10.24.4 Product Subclass 4: Pyrazino[1,2-a]indoles and Related Benzo-Fused Ring Systems

2021 ◽  
Author(s):  
P. A. Harris
Keyword(s):  
Indole Derivatives ◽  
Aryl Group ◽  
Ring Systems ◽  
Keto Ester ◽  
Fused Ring

AbstractThe synthesis of pyrazino[1,2-a]indoles and related indolo[1,2-a]quinoxalines and pyrido[2′,1′:3,4]pyrazino[1,2-a]indol-5-ium salts are reviewed in this chapter. The most common routes to pyrazino[1,2-a]indoles involve cyclization of indole derivatives containing a formyl, keto, ester, or nitrile function at the 2-position. Indolo[1,2-a]quinoxalines are most readily accessed via cyclization of 1-(aryl)-1H-indoles, where the aryl group is substituted at the 2-position by either amino, iodo, or nitro functionality.

10.24.2 Product Subclass 2: Pyrimido[1,2-a]indoles and Related Benzo-Fused Ring Systems

2021 ◽  
Author(s):  
P. A. Harris
Keyword(s):  
Ring Systems ◽  
Fused Ring

AbstractMethods for the synthesis of pyrimido[1,2-a]indoles and the related indolo[1,2-a]quinazoline and indolo[2,1-b]quinazoline ring systems are reviewed in this chapter. Although limited reports have been published to date, a variety of differing approaches to these heterocycles have been described.

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