Actin-Binding Marine Macrolides: Total Synthesis and Biological Importance

2002 ◽  
Vol 41 (24) ◽  
pp. 4632-4653 ◽  
Author(s):  
Kap-Sun Yeung ◽  
Ian Paterson
Keyword(s):  
Total Synthesis ◽  
Actin Binding ◽  
Biological Importance ◽  
Marine Macrolides

Total Synthesis and Evaluation of the Actin-Binding Properties of Microcarpalide (I) and a Focused Library of Analogues.

ChemInform ◽  
2007 ◽  
Vol 38 (24) ◽  
Author(s):  
Alois Fuerstner ◽  
Takashi Nagano ◽  
Christoph Mueller ◽  
Guenter Seidel ◽  
Oliver Mueller
Keyword(s):  
Total Synthesis ◽  
Actin Binding ◽  
Binding Properties

scholarly journals Diverted total synthesis: Preparation of a focused library of latrunculin analogues and evaluation of their actin-binding properties

2005 ◽  
Vol 102 (23) ◽  
pp. 8103-8108 ◽  
Author(s):  
A. Furstner ◽  
D. Kirk ◽  
M. D. B. Fenster ◽  
C. Aissa ◽  
D. De Souza ◽  
...  
Keyword(s):  
Total Synthesis ◽  
Actin Binding ◽  
Binding Properties

Advances in the Total Synthesis of Biologically Important Marine Macrolides

ChemInform ◽  
2006 ◽  
Vol 37 (16) ◽  
Author(s):  
Kap-Sun Yeung ◽  
Ian Paterson
Keyword(s):  
Total Synthesis ◽  
Marine Macrolides

Total synthesis of cytotoxic marine macrolides: Callipeltoside A, aurisides A and B, and dolastatin 19

2008 ◽  
Vol 80 (8) ◽  
pp. 1773-1782 ◽  
Author(s):  
Ian Paterson ◽  
Alison D. Findlay
Keyword(s):  
Total Synthesis ◽  
Conformational Analysis ◽  
Marine Origin ◽  
Total Syntheses ◽  
Stereochemical Assignment ◽  
Callipeltoside A ◽  
Marine Macrolides ◽  
Synthetic Studies

Synthetic studies pertaining to a novel class of structurally related glycosidic 14-membered macrolides of marine origin are reported. The evolution of a versatile aldol-based strategy that culminated in the total syntheses of callipeltoside A and aurisides A and B is detailed. Using a combination of biogenetic considerations and conformational analysis, a revised stereochemical assignment for the related polyketide dolastatin 19 was proposed and validated by total synthesis.

Total Synthesis and Evaluation of the Actin-Binding Properties of Microcarpalide and a Focused Library of Analogues

2007 ◽  
Vol 13 (5) ◽  
pp. 1452-1462 ◽  
Author(s):  
Alois Fürstner ◽  
Takashi Nagano ◽  
Christoph Müller ◽  
Günter Seidel ◽  
Oliver Müller
Keyword(s):  
Total Synthesis ◽  
Actin Binding ◽  
Binding Properties

Total Synthesis of Bioactive Marine Macrolides

1995 ◽  
Vol 95 (6) ◽  
pp. 2041-2114 ◽  
Author(s):  
Roger D. Norcross ◽  
Ian. Paterson
Keyword(s):  
Total Synthesis ◽  
Marine Macrolides

ChemInform Abstract: Total Synthesis of Bioactive Marine Macrolides

ChemInform ◽  
2010 ◽  
Vol 27 (5) ◽  
pp. no-no
Author(s):  
R. D. NORCROSS ◽  
I. PATERSON
Keyword(s):  
Total Synthesis ◽  
Marine Macrolides

Generation of Molecular Shape Diverstiy. From Privileged Scaffolds to Diverted Total Synthesis

2012 ◽  
Vol 1 (1) ◽  
Author(s):  
Wei-Min Dai
Keyword(s):  
Total Synthesis ◽  
Three Dimensional ◽  
Structural Diversity ◽  
Molecular Shape ◽  
Dimensional Structure ◽  
Diversity Oriented Synthesis ◽  
Biological Targets ◽  
Compound Libraries ◽  
Marine Macrolides ◽  
Potential Map

AbstractMolecular shape is a presentation of a molecule’s three-dimensional structure and its volume of space and surface electrostatic potential map collectively define the function, e. g. as a modulator or probe to biological targets. Molecular shape diversity for compound libraries with multiple scaffolds (rich skeletal diversity) is recognized as a prerequisite for discovering broad bioactivity. Established strategies and methodologies for diversity-oriented synthesis (DOS) are useful for generating molecular shape diversity by synthesizing natural product-like compounds. On the other hand, diverted total synthesis (DTS) offers natural products and analogues with a higher degree of structural diversity and complexity. Examples of DOS of privileged heterocycles and DTS of amphidinolide T marine macrolides from the author’s laboratories are illustrated.

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