scholarly journals Identification of the Enzymes Mediating the Maturation of the Seryl‐tRNA Synthetase Inhibitor SB‐217452 during the Biosynthesis of Albomycins

2020 ◽  
Vol 59 (9) ◽  
pp. 3558-3562 ◽  
Author(s):  
Richiro Ushimaru ◽  
Zhang Chen ◽  
Houyuan Zhao ◽  
Po‐hsun Fan ◽  
Hung‐wen Liu
Keyword(s):  
Trna Synthetase ◽  
Synthetase Inhibitor

Synthesis of conformationally restricted analogues of the tryptophanyl tRNA synthetase inhibitor indolmycin

1996 ◽  
Vol 37 (17) ◽  
pp. 3067-3070 ◽  
Author(s):  
David R. Witty ◽  
Graham Walker ◽  
John H. Bateson ◽  
Peter J. O'Hanlon ◽  
Drake S. Eggleston ◽  
...  
Keyword(s):  
Trna Synthetase ◽  
Synthetase Inhibitor ◽  
Conformationally Restricted

scholarly journals A potent prolyl tRNA synthetase inhibitor antagonizes Chikungunya and Dengue viruses

2019 ◽  
Vol 161 ◽  
pp. 163-168 ◽  
Author(s):  
Jesse Hwang ◽  
Alfred Jiang ◽  
Erol Fikrig
Keyword(s):  
Trna Synthetase ◽  
Dengue Viruses ◽  
Synthetase Inhibitor

Discovery of a Potent and Specific M. tuberculosis Leucyl-tRNA Synthetase Inhibitor: (S)-3-(Aminomethyl)-4-chloro-7-(2-hydroxyethoxy)benzo[c][1,2]oxaborol-1(3H)-ol (GSK656)

2017 ◽  
Vol 60 (19) ◽  
pp. 8011-8026 ◽  
Author(s):  
Xianfeng Li ◽  
Vincent Hernandez ◽  
Fernando L. Rock ◽  
Wai Choi ◽  
Yvonne S. L. Mak ◽  
...  
Keyword(s):  
Trna Synthetase ◽  
Synthetase Inhibitor

Identification of the Enzymes Mediating the Maturation of the Seryl‐tRNA Synthetase Inhibitor SB‐217452 during the Biosynthesis of Albomycins

2020 ◽  
Vol 132 (9) ◽  
pp. 3586-3590
Author(s):  
Richiro Ushimaru ◽  
Zhang Chen ◽  
Houyuan Zhao ◽  
Po‐hsun Fan ◽  
Hung‐wen Liu
Keyword(s):  
Trna Synthetase ◽  
Synthetase Inhibitor

Discovery of a novel prolyl-tRNA synthetase inhibitor and elucidation of its binding mode to the ATP site in complex with l -proline

2017 ◽  
Vol 488 (2) ◽  
pp. 393-399 ◽  
Author(s):  
Ryutaro Adachi ◽  
Kengo Okada ◽  
Robert Skene ◽  
Kazumasa Ogawa ◽  
Masanori Miwa ◽  
...  
Keyword(s):  
Binding Mode ◽  
Trna Synthetase ◽  
Synthetase Inhibitor

scholarly journals Biosynthesis of Albomycin δ2 Provides a Template for Assembling Siderophore and Aminoacyl-tRNA Synthetase Inhibitor Conjugates

2012 ◽  
Vol 7 (9) ◽  
pp. 1565-1575 ◽  
Author(s):  
Yu Zeng ◽  
Aditya Kulkarni ◽  
Zhaoyong Yang ◽  
Preeti B. Patil ◽  
Wei Zhou ◽  
...  
Keyword(s):  
Trna Synthetase ◽  
Aminoacyl Trna Synthetase ◽  
Synthetase Inhibitor

scholarly journals A Potent Seryl tRNA Synthetase Inhibitor SB-217452 Isolated from a Streptomyces species.

2000 ◽  
Vol 53 (12) ◽  
pp. 1346-1353 ◽  
Author(s):  
ANNA L. STEFANSKA ◽  
MARK FULSTON ◽  
CATHERINE S.V HOUGE-FRYDRYCH ◽  
Jo J. JONES ◽  
STEPHEN R. WARR
Keyword(s):  
Trna Synthetase ◽  
Streptomyces Species ◽  
Synthetase Inhibitor

Synthesis and activity of analogues of the isoleucyl tRNA synthetase inhibitor SB-203207

2003 ◽  
Vol 11 (13) ◽  
pp. 2687-2694 ◽  
Author(s):  
Curtis F Crasto ◽  
Andrew K Forrest ◽  
Tomislav Karoli ◽  
Darren R March ◽  
Lucy Mensah ◽  
...  
Keyword(s):  
Trna Synthetase ◽  
Synthetase Inhibitor

scholarly journals SB-219383, a Novel Tyrosyl tRNA Synthetase Inhibitor from a Micromonospora sp. II. Structure Determination.

2000 ◽  
Vol 53 (4) ◽  
pp. 351-356 ◽  
Author(s):  
CATHERINE S.V HOUGE-FRYDRYCH ◽  
SIMON A. READSHAW ◽  
DAVID J. BELL
Keyword(s):  
Structure Determination ◽  
Trna Synthetase ◽  
Synthetase Inhibitor

scholarly journals ComparativeIn VitroActivities of GSK2251052, a Novel Boron-Containing Leucyl-tRNA Synthetase Inhibitor, against 916 Anaerobic Organisms

2013 ◽  
Vol 57 (5) ◽  
pp. 2401-2404 ◽  
Author(s):  
Ellie J. C. Goldstein ◽  
Diane M. Citron ◽  
Kerin L. Tyrrell ◽  
C. Vreni Merriam
Keyword(s):  
Clostridium Perfringens ◽  
Bacteroides Fragilis ◽  
Trna Synthetase ◽  
Bacteroides Thetaiotaomicron ◽  
Content Type ◽  
Synthetase Inhibitor

ABSTRACTWe studied the comparativein vitroactivity of GSK2251052, a novel boron leucyl-tRNA synthetase inhibitor, against 916 clinical anaerobic isolates using CLSI methods. The GSK MIC50/MIC90for all isolates tested were 2 and 4 μg/ml, and the MIC90s against 302Bacteroides fragilisandBacteroides thetaiotaomicronstrains were 4 and 8 μg/ml, respectively. AllClostridium perfringensstrains had GSK2251052 MICs of >32 μg/ml. There was no relationship between increased MICs for any other antibiotics and that of GSK2251052.

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