The Journal of Antibiotics
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Published By Springer Nature

1881-1469, 0021-8820

Author(s):  
Shinji Kamisuki ◽  
Hisanobu Shibasaki ◽  
Koudai Ashikawa ◽  
Kazuki Kanno ◽  
Koichi Watashi ◽  
...  

Author(s):  
Benjamin J. Lethbridge ◽  
Robert E. Asenstorfer ◽  
Laura S. Bailey ◽  
Brenda T. Breil ◽  
Jodie V. Johnson ◽  
...  

AbstractTrifolitoxin (TFX, C41H63N15O15S) is a selective, ribosomally-synthesized, post-translationally modified, peptide antibiotic, produced by Rhizobium leguminosarum bv. trifolii T24. TFX specifically inhibits α-proteobacteria, including the plant symbiont Rhizobium spp., the plant pathogen Agrobacterium spp. and the animal pathogen Brucella abortus. TFX-producing strains prevent legume root nodulation by TFX-sensitive rhizobia. TFX has been isolated as a pair of geometric isomers, TFX1 and TFX2, which are derived from the biologically inactive primary amino acid sequence: Asp-Ile-Gly-Gly-Ser-Arg-Gln-Gly-Cys-Val-Ala. Gly-Cys is present as a thiazoline ring and the Arg-Gln-Gly sequence is extensively modified to a UV absorbing, blue fluorescent chromophore. The chromophore consists of a conjugated, 5-membered heterocyclic ring and side chain of modified glutamine.


Author(s):  
Kiyoko Fujita ◽  
Iichiro Takata ◽  
Ippei Yoshida ◽  
Hajime Takashima ◽  
Hiroyuki Sugiyama

Author(s):  
Ayumi Hikima ◽  
Shumpei Asamizu ◽  
Hiroyasu Onaka ◽  
Huiping Zhang ◽  
Hiroshi Tomoda ◽  
...  

Author(s):  
Dae-Won Ki ◽  
Dae-Won Kim ◽  
Ja-Gyeong Song ◽  
E-Eum Woo ◽  
Dae-Cheol Choi ◽  
...  
Keyword(s):  

Author(s):  
Heather Lacey ◽  
Rachel Chen ◽  
Daniel Vuong ◽  
Michael S. Cowled ◽  
Ernest Lacey ◽  
...  

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