Metal complex lipids for fluid–fluid phase separation in co‐assembled phospholipid membranes

2021 ◽  
Author(s):  
Ryo Ohtani ◽  
Yuka Anegawa ◽  
Hikaru Watanabe ◽  
Yutaro Tajima ◽  
Masanao Kinoshita ◽  
...  
Keyword(s):  
Phase Separation ◽  
Metal Complex ◽  
Fluid Phase ◽  
Phospholipid Membranes ◽  
Complex Lipids

Metal complex lipids for fluid–fluid phase separation in co‐assembled phospholipid membranes

2021 ◽  
Author(s):  
Ryo Ohtani ◽  
Yuka Anegawa ◽  
Hikaru Watanabe ◽  
Yutaro Tajima ◽  
Masanao Kinoshita ◽  
...  
Keyword(s):  
Phase Separation ◽  
Metal Complex ◽  
Fluid Phase ◽  
Phospholipid Membranes ◽  
Complex Lipids

β2-Glycoprotein I: Target antigen for ‘antiphospholipid’ antibodies. Immunological and molecular aspects

Lupus ◽  
1998 ◽  
Vol 7 (2_suppl) ◽  
pp. 5-9 ◽  
Author(s):  
Y Sheng ◽  
DA Kandiah ◽  
SA Krilis
Keyword(s):  
Antiphospholipid Syndrome ◽  
Antiphospholipid Antibodies ◽  
Fluid Phase ◽  
Target Antigen ◽  
Phospholipid Membranes ◽  
Anionic Phospholipid ◽  
Glycoprotein I ◽  
High Concentrations ◽  
Molecular Aspects ◽  
Anionic Phospholipid Membranes

It has become clear that β2-glycoprotein I (β2GPI) is the most common and best-characterised antigenic target for ‘antiphospholipid’ (aPL) autoantibodies. These antibodies preferentially bind β2GPI that has been immobilised on anionic phospholipid membranes or certain synthetic surfaces. These surfaces appear to act by increasing antigen density to allow binding of intrinsically low-affinity anti-β2GPI autoantibodies. Binding of β2GPI in fluid phase is weak and requires high concentrations of β2GPI. Our understanding of the pathophysiology of the ‘Antiphospholipid’ Syndrome (APS) has increased exponentially with the number of studies into the interactions of aPL antibodies and β2GPI.

scholarly journals Calcium-induced phase separation and fusion in phospholipid membranes

1975 ◽  
Vol 15 (9) ◽  
pp. 945-948 ◽  
Author(s):  
D. Papahadjopoulos ◽  
G. Poste
Keyword(s):  
Phase Separation ◽  
Phospholipid Membranes
Sign in / Sign up

Export Citation Format

Share Document