The characteristic and kinetic studies on the enantioselective hydrolysis of (R,S)-α-ethyl-2-oxo-1-pyrrolidine acetic acid ethyl ester catalyzed byTsukamurella tyrosinosolvensE105-derived hydrolase

2014 ◽  
Vol 9 (6) ◽  
pp. 941-949 ◽  
Author(s):  
Jin Huang ◽  
Ren Yan ◽  
Haifang Shi ◽  
Pu Wang ◽  
Junyao He
Keyword(s):  
Acetic Acid ◽  
Ethyl Ester ◽  
Acid Ethyl Ester ◽  
Kinetic Studies ◽  
Enantioselective Hydrolysis ◽  
Hydrolysis Of

Synthesen von Heterocyclen, CC Reaktionen mit cyclischen Oxalylverbindungen, XVIII Zur Reaktion von 4-Benzoyl-5-phenyl-2,3-dihydrofuran-2,3-dion mit Η-aktiven Nucleophilen. / Syntheses of Heterocycles, CC Reactions of Cyclic Oxalyl Compounds, XVIII The Reaction of 4-Benzoyl-5-phenyl-2,3-dihydrofuran-2,3-dione with Η-active Nucleophiles

1976 ◽  
Vol 31 (11) ◽  
pp. 1511-1514 ◽  
Author(s):  
Gert Kollenz ◽  
Erich Ziegler ◽  
Walter Ott ◽  
Herwig Igel
Keyword(s):  
Acetic Acid ◽  
Acrylic Acid ◽  
Oxalic Acid ◽  
Ethyl Ester ◽  
Acid Ethyl Ester ◽  
The Other ◽  
Other Hand ◽  
Hydrolysis Of ◽  
Acid Anilides

Hydrolysis of 4-Benzoyl-5-phenyl-2,3-dihydrofuran-2,3-dione (1) in water (ethanol) gives dibenzoylmethane and oxalic acid (ethyl ester). 1 reacts with aniline or p-toluidine yielding the 2-pyrrolones (2), which on the other hand are synthesized by addition of the corresponding anilines to the pyrrol-2,3-diones (8). 3 a adds methanol to give the 2-pyrrolone (4), which with aniline can be converted into 2 a. 2 a, b show fragmentation to oxalic acid anilides by heating (2 b) or treating with diazomethane (2 a). The reaction of 1 with p-nitroaniline leads via the furanone-derivative 6 to oxalic acid-di-p-nitroanilide. 1 and N-methylaniline combine to acrylic acid-N-methylanilide (7), which by heating gives the dibenzoyl acetic acid-N-methylanilide

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