Design, synthesis, molecular modeling, and antimicrobial potential of novel 3‐[(1 H ‐pyrazol‐3‐yl)imino]indolin‐2‐one derivatives as DNA gyrase inhibitors

2021 ◽  
Author(s):  
Abdullah Y. Alzahrani ◽  
Yousry A. Ammar ◽  
Mohamed A. Salem ◽  
Mohammed Abu‐Elghait ◽  
Ahmed Ragab
Keyword(s):  
Molecular Modeling ◽  
Dna Gyrase ◽  
Design Synthesis ◽  
Antimicrobial Potential ◽  
Gyrase Inhibitors

ChemInform Abstract: Design, Synthesis, and Structure-Activity Relationship Studies of ATP Analogues as DNA Gyrase Inhibitors.

ChemInform ◽  
2010 ◽  
Vol 31 (30) ◽  
pp. no-no
Author(s):  
Thomas Luebbers ◽  
Peter Angehrn ◽  
Hans Gmuender ◽  
Silvia Herzig ◽  
Josef Kulhanek
Keyword(s):  
Dna Gyrase ◽  
Structure Activity Relationship ◽  
Activity Relationship ◽  
Design Synthesis ◽  
Structure Activity ◽  
Atp Analogues ◽  
Gyrase Inhibitors

scholarly journals Design, synthesis and biological evaluation of 4,5-dibromo-N-(thiazol-2-yl)-1H-pyrrole-2-carboxamide derivatives as novel DNA gyrase inhibitors

2017 ◽  
Vol 25 (1) ◽  
pp. 338-349 ◽  
Author(s):  
Tihomir Tomašič ◽  
Matic Mirt ◽  
Michaela Barančoková ◽  
Janez Ilaš ◽  
Nace Zidar ◽  
...  
Keyword(s):  
Dna Gyrase ◽  
Biological Evaluation ◽  
Design Synthesis ◽  
Synthesis And Biological Evaluation ◽  
Gyrase Inhibitors

Novel 1,2,4-oxadiazole-chalcone/oxime hybrids as potential antibacterial DNA gyrase inhibitors: Design, synthesis, ADMET prediction and molecular docking study

2021 ◽  
pp. 104885
Author(s):  
Tarek S. Ibrahim ◽  
Ahmad J. Almalki ◽  
Amr H. Moustafa ◽  
Rasha M. Allam ◽  
Gamal El-Din A. Abuo-Rahma ◽  
...  
Keyword(s):  
Molecular Docking ◽  
Dna Gyrase ◽  
Docking Study ◽  
Molecular Docking Study ◽  
Design Synthesis ◽  
Gyrase Inhibitors

Esterprodrugs of ciprofloxacin as DNA-gyrase inhibitors: synthesis, antiparasitic evaluation and docking studies

MedChemComm ◽  
2011 ◽  
Vol 2 (5) ◽  
pp. 430-435 ◽  
Author(s):  
Faustine Dubar ◽  
René Wintjens ◽  
Érica S. Martins-Duarte ◽  
Rossiane C. Vommaro ◽  
Wanderley de Souza ◽  
...  
Keyword(s):  
Plasmodium Falciparum ◽  
Molecular Modeling ◽  
Toxoplasma Gondii ◽  
Dna Gyrase ◽  
Docking Studies ◽  
Mechanisms Of Action ◽  
Computational Calculations ◽  
Gyrase Inhibitors ◽  
Ester Prodrugs

Novel ester prodrugs of ciprofloxacin proved to be extremely efficient against Plasmodium falciparum and Toxoplasma gondii. Molecular modeling and computational calculations were used to understand the mechanisms of action of these drugs.

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