Preparation and clinical translation of 99mTc-PSMA-11 for SPECT imaging of prostate cancer

This study explores the feasibility of radiolabeling the HBED-CC-PSMA (PSMA-11) ligand with Tc-99m for SPECT imaging of prostate cancer patients.

Rational design of novel amphipathic antimicrobial peptides focused on the distribution of cationic amino acid residues

Amphipathic helical peptideStripeshowed high antimicrobial activity, low hemolytic activity, and low human cell cytotoxicity.

Identification of the first enantiopure Rac1–Tiam1 protein–protein interaction inhibitor and its optimized synthesis via phosphine free remote group directed hydroarylation

The remote substituent regiocontrol of phosphine free Heck hydroarylation has been exploited for the preparation of the first enantiopure inhibitor of Rac1–Tiam1 PPI.

Lipidomic analysis as a tool for identifying susceptibility to various skin diseases

This review is about the significance of the use of lipidomic analysis for identifying susceptibility to skin diseases.

Fluorine substituted methoxyphenylalkyl amides as potent melatonin receptor agonists

A series of fluorine substituted methoxyphenylalkyl amides were prepared with different orientations of the fluorine and methoxy groups with respect to the alkylamide side chain and with alkyl sides of differing lengths (n= 1–3).

Synthesis and biological evaluation of structurally diverse α-conformationally restricted chalcones and related analogues

Cyclic chalcones and structural analogues evaluated as cytotoxic agents.

Tailored therapeutics based on 1,2,3-1H-triazoles: a mini review

Contemporary drug discovery approaches rely on library synthesis coupled with combinatorial methods and high-throughput screening to identify leads.

Synthesis and antitumor activity of fluorouracil – oleanolic acid/ursolic acid/glycyrrhetinic acid conjugates

Due to the obvious adverse effects of 5-fluorouracil and considering the diverse biological activities of pentacyclic triterpenes, twelve pentacyclic triterpene-5-fluorouracil conjugates were synthesized and their antitumor activities were evaluated.

Synthesis of N-acyl amide natural products using a versatile adenylating biocatalyst

TamA is the enzyme that controls the acyl chain length of the tambjamine natural products. Here we show that the catalytic ANL domain of TamA can be used to prepare a range of N-acyl amides.