Understanding mAb aggregation during low pH viral inactivation and subsequent neutralization

2019 ◽  
Vol 117 (3) ◽  
pp. 687-700
Author(s):  
Ruben Wälchli ◽  
Mariana Ressurreição ◽  
Sebastian Vogg ◽  
Fabian Feidl ◽  
James Angelo ◽  
...  
Keyword(s):  
Low Ph ◽  
Viral Inactivation ◽  
Subsequent Neutralization

Design of a novel continuous flow reactor for low pH viral inactivation

2017 ◽  
Vol 115 (3) ◽  
pp. 606-616 ◽  
Author(s):  
Stephanie A. Parker ◽  
Linus Amarikwa ◽  
Kevin Vehar ◽  
Raquel Orozco ◽  
Scott Godfrey ◽  
...  
Keyword(s):  
Continuous Flow ◽  
Flow Reactor ◽  
Low Ph ◽  
Viral Inactivation ◽  
Continuous Flow Reactor

Simulation of pH level distribution inside a coiled flow inverter for continuous low pH viral inactivation

2019 ◽  
Vol 117 (2) ◽  
pp. 429-437 ◽  
Author(s):  
Laura David ◽  
Lisa Marie Waldschmidt ◽  
Martin Lobedann ◽  
Gerhard Schembecker
Keyword(s):  
Low Ph ◽  
Viral Inactivation ◽  
Ph Level

Retrospective Evaluation of Low-pH Viral Inactivation and Viral Filtration Data from a Multiple Company Collaboration

2016 ◽  
Vol 70 (3) ◽  
pp. 293-299 ◽  
Author(s):  
J. Mattila ◽  
M. Clark ◽  
S. Liu ◽  
J. Pieracci ◽  
T. R. Gervais ◽  
...  
Keyword(s):  
Low Ph ◽  
Retrospective Evaluation ◽  
Viral Inactivation

Continuous viral inactivation at low pH value in antibody manufacturing

2016 ◽  
Vol 102 ◽  
pp. 88-101 ◽  
Author(s):  
Stephan Klutz ◽  
Martin Lobedann ◽  
Christian Bramsiepe ◽  
Gerhard Schembecker
Keyword(s):  
Ph Value ◽  
Low Ph ◽  
Viral Inactivation

scholarly journals Protein aggregation and mitigation strategy in low pH viral inactivation for monoclonal antibody purification

mAbs ◽  
2019 ◽  
Vol 11 (8) ◽  
pp. 1479-1491 ◽  
Author(s):  
Weixin Jin ◽  
Zizhuo Xing ◽  
Yuanli Song ◽  
Chao Huang ◽  
Xuankuo Xu ◽  
...  
Keyword(s):  
Monoclonal Antibody ◽  
Protein Aggregation ◽  
Low Ph ◽  
Mitigation Strategy ◽  
Viral Inactivation ◽  
Antibody Purification

Viral Inactivation: Low pH and Detergent

2015 ◽  
Vol 69 (1) ◽  
pp. 163-172 ◽  
Author(s):  
L. Durno ◽  
O. Tounekti
Keyword(s):  
Low Ph ◽  
Viral Inactivation

Virus study for continuous low pH viral inactivation inside a coiled flow inverter

2018 ◽  
Vol 116 (4) ◽  
pp. 857-869 ◽  
Author(s):  
Laura David ◽  
Benjamin Maiser ◽  
Martin Lobedann ◽  
Peter Schwan ◽  
Michael Lasse ◽  
...  
Keyword(s):  
Low Ph ◽  
Viral Inactivation

Erratum for John Mattila, Mike Clark, Shengjiang Liu, et al.: “Retrospective Evaluation of Low-pH Viral Inactivation and Viral Filtration Data from a Multiple Company Collaboration”

2018 ◽  
Vol 72 (4) ◽  
pp. 451-451
Author(s):  
John Mattila ◽  
Mike Clark ◽  
Shengjiang Liu ◽  
John Pieracci ◽  
Thomas R. Gervais ◽  
...  
Keyword(s):  
Low Ph ◽  
Retrospective Evaluation ◽  
Viral Inactivation

Low pH, caprylate incubation as a second viral inactivation step in the manufacture of albumin

Biologicals ◽  
2003 ◽  
Vol 31 (3) ◽  
pp. 213-221 ◽  
Author(s):  
Anna Johnston ◽  
Eric Uren ◽  
David Johnstone ◽  
John Wu
Keyword(s):  
Low Ph ◽  
Viral Inactivation

scholarly journals Truly continuous low pH viral inactivation for biopharmaceutical process integration

2020 ◽  
Vol 117 (5) ◽  
pp. 1406-1417 ◽  
Author(s):  
Duarte L. Martins ◽  
Jure Sencar ◽  
Nikolaus Hammerschmidt ◽  
Andreas Flicker ◽  
Johanna Kindermann ◽  
...  
Keyword(s):  
Process Integration ◽  
Low Ph ◽  
Viral Inactivation
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