Recent Advances in Late‐Stage Construction of Stapled Peptides via C−H Activation

ChemBioChem ◽  
2021 ◽  
Author(s):  
Jiang Liu ◽  
Peng Wang ◽  
Zhengqing Yan ◽  
Jiahui Yan ◽  
Kenry ◽  
...  
Keyword(s):  
Late Stage ◽  
Stapled Peptides ◽  
Recent Advances

Late-Stage Diversification through Manganese-Catalyzed C−H Activation: Access to Acyclic, Hybrid, and Stapled Peptides

2019 ◽  
Vol 131 (11) ◽  
pp. 3514-3518 ◽  
Author(s):  
Nikolaos Kaplaneris ◽  
Torben Rogge ◽  
Rongxin Yin ◽  
Hui Wang ◽  
Giedre Sirvinskaite ◽  
...  
Keyword(s):  
Late Stage ◽  
Stapled Peptides

Late‐Stage Peptide Diversification through Cobalt‐Catalyzed C−H Activation: Sequential Multicatalysis for Stapled Peptides

2019 ◽  
Vol 58 (6) ◽  
pp. 1684-1688 ◽  
Author(s):  
Mélanie M. Lorion ◽  
Nikolaos Kaplaneris ◽  
Jongwoo Son ◽  
Rositha Kuniyil ◽  
Lutz Ackermann
Keyword(s):  
Late Stage ◽  
Stapled Peptides

scholarly journals Biocatalytic Alkylation Cascades: Recent Advances and Future Opportunities for Late‐Stage Functionalization

ChemBioChem ◽  
2020 ◽  
Vol 21 (20) ◽  
pp. 2890-2897 ◽  
Author(s):  
Iain J. W. McKean ◽  
Paul A. Hoskisson ◽  
Glenn A. Burley
Keyword(s):  
Late Stage ◽  
Recent Advances

Stapled Peptides by Late-Stage C(sp3 )−H Activation

2016 ◽  
Vol 56 (1) ◽  
pp. 314-318 ◽  
Author(s):  
Anaïs F. M. Noisier ◽  
Jesús García ◽  
Ioana A. Ionuţ ◽  
Fernando Albericio
Keyword(s):  
Late Stage ◽  
Stapled Peptides

scholarly journals Recent Advances in Transition-Metal-Free Late-Stage C-H and N-H Arylation of Heteroarenes Using Diaryliodonium Salts

2021 ◽  
Vol 14 (7) ◽  
pp. 661
Author(s):  
Thierry Besson ◽  
Corinne Fruit
Keyword(s):  
Transition Metal ◽  
Late Stage ◽  
Heterocyclic Compounds ◽  
Environmentally Friendly ◽  
Direct Arylation ◽  
Stepping Stone ◽  
Metal Free ◽  
Bond Forming ◽  
Diaryliodonium Salts ◽  
Recent Advances

Transition-metal-free direct arylation of C-H or N-H bonds is one of the key emerging methodologies that is currently attracting tremendous attention. Diaryliodonium salts serve as a stepping stone on the way to alternative environmentally friendly and straightforward pathways for the construction of C-C and C-heteroatom bonds. In this review, we emphasize the recent synthetic advances of late-stage C(sp2)-N and C(sp2)-C(sp2) bond-forming reactions under metal-free conditions using diaryliodonium salts as arylating reagent and its applications to the synthesis of new arylated bioactive heterocyclic compounds.

Late-Stage Diversification through Manganese-Catalyzed C−H Activation: Access to Acyclic, Hybrid, and Stapled Peptides

2019 ◽  
Vol 58 (11) ◽  
pp. 3476-3480 ◽  
Author(s):  
Nikolaos Kaplaneris ◽  
Torben Rogge ◽  
Rongxin Yin ◽  
Hui Wang ◽  
Giedre Sirvinskaite ◽  
...  
Keyword(s):  
Late Stage ◽  
Stapled Peptides

scholarly journals Late stage modifications of P-containing ligands using transition-metal-catalysed C–H bond functionalisation

2018 ◽  
Vol 54 (53) ◽  
pp. 7265-7280 ◽  
Author(s):  
Zhuan Zhang ◽  
Pierre H. Dixneuf ◽  
Jean-François Soulé
Keyword(s):  
Transition Metal ◽  
Late Stage ◽  
Phosphine Ligands ◽  
Recent Advances

Recent advances in C–H bond functionalisation of phosphorus derivatives are presented, with a special attention to preparation of phosphine ligands.

Green chemistry meets medicinal chemistry: a perspective on modern metal-free late-stage functionalization reactions

2021 ◽  
Author(s):  
Juan D. Lasso ◽  
Durbis J. Castillo-Pazos ◽  
Chao-Jun Li
Keyword(s):  
Green Chemistry ◽  
Functional Groups ◽  
Late Stage ◽  
Medicinal Chemistry ◽  
Metal Free ◽  
Recent Advances

This review summarizes the most recent advances of metal-free late-stage functionalization (LSF) of pharmaceutically relevant molecules. Particular emphasis is placed on C–H activation as well as the use of endogenous functional groups.

Late-Stage Construction of Stapled Peptides through Fujiwara-Moritani Reaction between Tryptophan and Olefines

2021 ◽  
Author(s):  
Jiang Liu ◽  
Peng Wang ◽  
Wei Zeng ◽  
Qi Lu ◽  
Qing Zhu
Keyword(s):  
Late Stage ◽  
Stapled Peptides ◽  
Peptide Modification ◽  
Palladium Catalyzed

Herein, the first example of palladium-catalyzed Fujiwara-Moritani reaction for olefination of tryptophan (Trp) residue, free from directing groups was presented. The developed reaction performs efficiently for peptide modification, ligation and...

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