In people with primary hypertension, what are the effects of epithelial sodium channel blockers on blood pressure when given as monotherapy or combined with other antihypertensive agents?

Primary Hypertension ◽

Channel Blockers ◽

Faculty Opinions recommendation of Blood pressure lowering efficacy of potassium-sparing diuretics (that block the epithelial sodium channel) for primary hypertension.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.717964665.793470389 ◽

2013 ◽

Author(s):

Bo Carlberg ◽

Mattias Brunström

Keyword(s):

Blood Pressure ◽

Sodium Channel ◽

Primary Hypertension ◽

Blood Pressure Lowering ◽

Blood pressure lowering efficacy of potassium-sparing diuretics (that block the epithelial sodium channel) for primary hypertension

10.1002/14651858.cd008167.pub2 ◽

2010 ◽

Cited By ~ 1

Author(s):

Balraj S Heran ◽

Jenny MH Chen ◽

Josh J Wang ◽

James M Wright

Keyword(s):

Blood Pressure ◽

Sodium Channel ◽

Primary Hypertension ◽

Blood Pressure Lowering ◽

Design, Synthesis, and Structure−Activity Relationships of Novel 2-Substituted Pyrazinoylguanidine Epithelial Sodium Channel Blockers: Drugs for Cystic Fibrosis and Chronic Bronchitis

Journal of Medicinal Chemistry ◽

10.1021/jm051134w ◽

2006 ◽

Vol 49 (14) ◽

pp. 4098-4115 ◽

Cited By ~ 59

Author(s):

Andrew J. Hirsh ◽

Bruce F. Molino ◽

Jianzhong Zhang ◽

Nadezhda Astakhova ◽

William B. Geiss ◽

...

Keyword(s):

Cystic Fibrosis ◽

Sodium Channel ◽

Chronic Bronchitis ◽

Channel Blockers ◽

Sodium Channel Blockers ◽

Design Synthesis ◽

Structure Activity Relationships ◽

Structure Activity

Blood pressure lowering efficacy of potassium-sparing diuretics (that block the epithelial sodium channel) for primary hypertension

Cochrane Database of Systematic Reviews ◽

10.1002/14651858.cd008167.pub3 ◽

2012 ◽

Cited By ~ 6

Author(s):

Balraj S Heran ◽

Jenny MH Chen ◽

Josh J Wang ◽

James M Wright

Keyword(s):

Blood Pressure ◽

Sodium Channel ◽

Primary Hypertension ◽

Blood Pressure Lowering ◽

Blood pressure lowering efficacy of potassium-sparing diuretics (that block the epithelial sodium channel) for primary hypertension

10.1002/14651858.cd008167 ◽

2009 ◽

Author(s):

Josh J Wang ◽

Balraj S Heran ◽

James M Wright

Keyword(s):

Blood Pressure ◽

Sodium Channel ◽

Primary Hypertension ◽

Blood Pressure Lowering ◽

Faculty Opinions recommendation of Inhibition of nociceptors by TRPV1-mediated entry of impermeant sodium channel blockers.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.1092130.553236 ◽

2007 ◽

Author(s):

David Archer

Keyword(s):

Sodium Channel ◽

Channel Blockers ◽

Sodium channel blockers for cystic fibrosis

10.1002/14651858.cd005087 ◽

2005 ◽

Cited By ~ 1

Author(s):

E Burrows ◽

KW Southern ◽

P Noone

Keyword(s):

Cystic Fibrosis ◽

Sodium Channel ◽

Channel Blockers ◽

Reconsidering the role of selective sodium channel blockers in genetic generalized epilepsy

Acta Neurologica Scandinavica ◽

10.1111/ane.13509 ◽

2021 ◽

Author(s):

Emanuele Cerulli Irelli ◽

Alessandra Morano ◽

Martina Fanella ◽

Biagio Orlando ◽

Enrico M Salamone ◽

...

Keyword(s):

Sodium Channel ◽

Channel Blockers ◽

Sodium Channel Blockers ◽

Generalized Epilepsy

ChemInform Abstract: Substituted Biaryl Pyrazoles as Sodium Channel Blockers.

ChemInform ◽

10.1002/chin.201052122 ◽

2010 ◽

Vol 41 (52) ◽

pp. no-no

Author(s):

Sriram Tyagarajan ◽

et al. et al.

Keyword(s):

Sodium Channel ◽

Channel Blockers ◽

Diphenytoin, riluzole and lidocaine: Three sodium channel blockers, with different mechanisms of action, decrease hippocampal epileptiform activity

Neuropharmacology ◽

10.1016/j.neuropharm.2013.04.057 ◽

2013 ◽

Vol 73 ◽

pp. 48-55 ◽

Cited By ~ 10

Author(s):

Lihong Diao ◽

Jennifer L. Hellier ◽

Jessica Uskert-Newsom ◽

Philip A. Williams ◽

Kevin J. Staley ◽

...

Keyword(s):

Sodium Channel ◽

Epileptiform Activity ◽

Mechanisms Of Action ◽

Channel Blockers ◽