Design, Synthesis, and Structure−Activity Relationships of Novel 2-Substituted Pyrazinoylguanidine Epithelial Sodium Channel Blockers:  Drugs for Cystic Fibrosis and Chronic Bronchitis

2006 ◽  
Vol 49 (14) ◽  
pp. 4098-4115 ◽  
Author(s):  
Andrew J. Hirsh ◽  
Bruce F. Molino ◽  
Jianzhong Zhang ◽  
Nadezhda Astakhova ◽  
William B. Geiss ◽  
...  
Keyword(s):  
Cystic Fibrosis ◽  
Sodium Channel ◽  
Chronic Bronchitis ◽  
Epithelial Sodium Channel ◽  
Channel Blockers ◽  
Sodium Channel Blockers ◽  
Design Synthesis ◽  
Structure Activity Relationships ◽  
Structure Activity

Synthesis and Structure−Activity Relationships of 6,7-Benzomorphan Derivatives as Use-Dependent Sodium Channel Blockers for the Treatment of Stroke

2002 ◽  
Vol 45 (17) ◽  
pp. 3755-3764 ◽  
Author(s):  
Matthias Grauert ◽  
Wolf D. Bechtel ◽  
Thomas Weiser ◽  
Werner Stransky ◽  
Herbert Nar ◽  
...  
Keyword(s):  
Sodium Channel ◽  
Channel Blockers ◽  
Sodium Channel Blockers ◽  
Structure Activity Relationships ◽  
Structure Activity

Sodium channel blockers for cystic fibrosis

2006 ◽  
Author(s):  
Elinor F Burrows ◽  
Kevin W Southern ◽  
Peadar G Noone
Keyword(s):  
Cystic Fibrosis ◽  
Sodium Channel ◽  
Channel Blockers ◽  
Sodium Channel Blockers

Sodium channel blockers for cystic fibrosis

2012 ◽  
Author(s):  
Elinor F Burrows ◽  
Kevin W Southern ◽  
Peadar G Noone
Keyword(s):  
Cystic Fibrosis ◽  
Sodium Channel ◽  
Channel Blockers ◽  
Sodium Channel Blockers
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