What are the benefits and harms of nitric oxide donors for cervical ripening in first-trimester surgical abortion?

2015 ◽  
Author(s):  
Charalampos Siristatidis
Keyword(s):  
Nitric Oxide ◽  
First Trimester ◽  
Cervical Ripening ◽  
Nitric Oxide Donors ◽  
Surgical Abortion

Nitric oxide donors for cervical ripening in first-trimester surgical abortion

2009 ◽  
Author(s):  
Patama Promsonthi ◽  
Domerudee Preechapornprasert ◽  
Boonsri Chanrachakul
Keyword(s):  
Nitric Oxide ◽  
First Trimester ◽  
Cervical Ripening ◽  
Nitric Oxide Donors ◽  
Surgical Abortion

Nitric oxide donors for cervical ripening in first-trimester surgical abortion

2011 ◽  
Author(s):  
Patama Promsonthi ◽  
Domerudee Preechapornprasert ◽  
Boonsri Chanrachakul
Keyword(s):  
Nitric Oxide ◽  
First Trimester ◽  
Cervical Ripening ◽  
Nitric Oxide Donors ◽  
Surgical Abortion

Nitric oxide donors for cervical ripening in first trimester for termination of pregnancy

2008 ◽  
Author(s):  
Patama Promsonthi ◽  
Domerudee Preechapornprasert ◽  
Boonsri Chanrachakul
Keyword(s):  
Nitric Oxide ◽  
First Trimester ◽  
Termination Of Pregnancy ◽  
Cervical Ripening ◽  
Nitric Oxide Donors

Nitric oxide donors induce cervical ripening in first trimester human pregnancy

1997 ◽  
Vol 176 (1) ◽  
pp. S172
Author(s):  
A.J. Thomson ◽  
C.B. Lunan ◽  
A.D. Cameron ◽  
I.T. Cameron ◽  
I.A. Creer ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
First Trimester ◽  
Cervical Ripening ◽  
Nitric Oxide Donors ◽  
Human Pregnancy

Randomised Trial of Nitric Oxide Donor Versus Prostaglandin for Cervical Ripening Before First-Trimester Termination of Pregnancy

1999 ◽  
Vol 54 (4) ◽  
pp. 251-252
Author(s):  
Andrew J. Thomson ◽  
C. Burnett Lunan ◽  
Marieanne Ledingham ◽  
Robert C. L. Howat ◽  
Iain T. Cameron ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Randomised Trial ◽  
First Trimester ◽  
Termination Of Pregnancy ◽  
Cervical Ripening ◽  
Nitric Oxide Donor

Intravaginal isosorbide mononitrate in addition to misoprostol versus misoprostol only for induction of labor: a randomized controlled trial

QJM ◽  
2020 ◽  
Vol 113 (Supplement_1) ◽  
Author(s):  
H M Harb ◽  
D Y Mansour ◽  
Y M A M E Abouahmed
Keyword(s):  
Nitric Oxide ◽  
Clinical Trial ◽  
Active Phase ◽  
Induction Of Labor ◽  
Cervical Ripening ◽  
Isosorbide Mononitrate ◽  
Nitric Oxide Donors ◽  
P Value ◽  
Delivery Time ◽  
Whole Process

Abstract Background Induction of labor is still a controversial obstetric procedure. The need to shorten delivery time has been recognized and practiced for centuries. Although the indications have clearly changed during the past decades from a need to expel a dead fetus to an effective solution to reduce the threat to the mother and her precious fetus, effective and safe methods of achieving delivery must always have been the primary objectives. Induction is indicated when the benefits to either mother or fetus outweigh those of pregnancy continuation. Nitric oxide donors(NO donors) such as isosorbide mononitrate could be of a great use for cervical ripening because of their effect on release of prostaglandins and vasodilation while having no or little effect on uterine activity ; since they are relatively safe and has low number of non-vital adverse effect if used with caution, they could be added to misoprostol to shorten to time needed for cervical ripening thus accelerating the whole process of induction of labor. The Aim of this study was to evaluate safety & efficacy of nitric oxide donors such as intravaginal isosorbide mononitrate in addition to misoprostol versus misoprostol only for the whole process of induction of labor. Patients and Methods in a prospective randomized double-blind placebo-controlled clinical trial which was conducted at Ain Shams Maternity University Hospital in Cairo from January 2018 to June 2018, 50 women were included in induction of labor, they were randomly divided into 2 group: Group I consisted of 25 patients, each patient was given 1 tablet of isosorbide mononitrate 40mg vaginally once and one tablet of misoprostol 25mcg vaginally; Group II consisted of 25 patients, each patient was given 1 tablet of misoprostol 25mcg vaginally. Misoprostol were given for a maximum of 5 doses (one 25mcg vaginal tablet) with interval of 6 hours between each tablet. This clinical trial was registered in clinicaltrial.gov registry with number: NCT03523754. Results there was a statistically significant difference between Isosorbide mononitrate & Misoprostol group versus Misoprostol only group regarding induction to delivery time ( mean 19.55 ± 1.41 to 22.94 ± 1.44 hours respectively, P-value <0.001) , induction to active phase interval (mean 10.67 ± 1.83 to 13.81 ± 0.52 hours respectively, P-value <0.001), maternal headache (36% to 12% respectively, P-value =0.047). Conclusion Isosorbide mononitrate appears to be a safe agent when used with misoprostol for induction of labor. It decreases induction to delivery time and induction to active phase time.

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