Structure Investigation of TiIV-BODOLates Involved in the Catalytic Asymmetric Reduction of Ketones Using Catecholborane

2004 ◽  
Vol 10 (1) ◽  
pp. 182-189 ◽  
Author(s):  
Ian Sarvary ◽  
Per-Ola Norrby ◽  
Torbjörn Frejd
Keyword(s):  
Asymmetric Reduction ◽  
Structure Investigation ◽  
Catalytic Asymmetric ◽  
Reduction Of Ketones

Penicillamine as a ligand in the catalytic asymmetric reduction of ketones

2002 ◽  
Vol 80 (8) ◽  
pp. 885-888 ◽  
Author(s):  
Stephen Hanessian ◽  
Eric Jnoff ◽  
Andrew M Griffin
Keyword(s):  
Amino Acids ◽  
Amino Acid ◽  
Asymmetric Reduction ◽  
Catalytic Asymmetric ◽  
Reduction Of Ketones

Amino acids derived from D-penicillamine and thiazolidines were studied as ligands for the catalytic asymmetric reduction of ketones with borane. Enantioselectivities up to 83% ee were observed.Key words: asymmetric reduction, penicillamine, thiazolidine, amino acid.

Novel chiral C2-symmetric multidentate aminophosphine ligands for use in catalytic asymmetric reduction of ketones

2013 ◽  
Vol 24 (6) ◽  
pp. 527-530 ◽  
Author(s):  
Ya-Qing Xu ◽  
Shen-Luan Yu ◽  
Yan-Yun Li ◽  
Zhen-Rong Dong ◽  
Jing-Xing Gao
Keyword(s):  
Asymmetric Reduction ◽  
Catalytic Asymmetric ◽  
Reduction Of Ketones

scholarly journals Asymmetric Synthetic Strategies of (R)-(–)-Baclofen: An Antispastic Drug

Synthesis ◽  
2017 ◽  
Vol 50 (02) ◽  
pp. 211-226 ◽  
Author(s):  
Perla Ramesh ◽  
Devatha Suman ◽  
Koti Reddy
Keyword(s):  
Asymmetric Reduction ◽  
Asymmetric Hydrogenation ◽  
Asymmetric Aldol ◽  
Asymmetric Michael Addition ◽  
Chemical Resolution ◽  
Enzymatic Desymmetrization ◽  
Catalytic Asymmetric ◽  
Aldol Addition ◽  
Synthetic Approaches ◽  
Catalytic Asymmetric Hydrogenation

Baclofen is an antispastic drug used as a muscle relaxant in the treatment of the paroxysmal pain of trigeminal neuralgia, spasticity of the spinal cord and cerebral origin. Baclofen resides biological activity exclusively in its (R)-(–)-enantiomer. In this review, various asymmetric synthetic strategies for (R)-(–)-baclofen are described.1 Introduction2 Resolution Synthetic Approaches2.1 Chemical Resolution2.2 Biocatalytic Resolution3 Asymmetric Desymmetrization3.1 Catalytic Enantioselective Desymmetrization3.2 Enzymatic Desymmetrization4 Chiral Auxiliary Induced Asymmetric Synthesis4.1 Asymmetric Michael Addition4.2 Asymmetric Aldol Addition4.3 Asymmetric Nucleophilic Substitution5 Asymmetric Reduction5.1 Catalytic Asymmetric Hydrogenation5.2 Bioreduction6 Catalytic Asymmetric Conjugate Addition7 Conclusion

Chiral phosphinamides: new catalysts for the asymmetric reduction of ketones by borane

1998 ◽  
pp. 1027-1038 ◽  
Author(s):  
Barry Burns ◽  
N. Paul King ◽  
Heather Tye ◽  
John R. Studley ◽  
Mark Gamble ◽  
...  
Keyword(s):  
Asymmetric Reduction ◽  
Reduction Of Ketones
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