ChemInform Abstract: AMINO ACIDS AND PEPTIDES. PART CXLIII. (1-β-MERCAPTOPROPIONIC ACID, 4-ASPARAGINE, 8-D-ARGININE)VASOPRESSIN, AN ANALOG WITH A HIGH AND VERY PURE ANTIDIURETIC ACTIVITY

1978 ◽  
Vol 9 (13) ◽  
Author(s):  
M. ZAORAL ◽  
I. BLAHA
Keyword(s):  
Amino Acids ◽  
Arginine Vasopressin ◽  
Mercaptopropionic Acid ◽  
Antidiuretic Activity

Synthesis of [1-β-mercaptopropionic acid, 8-D-arginine]vasopressin (DDAVP) in solid phase. Simple optimalization

1979 ◽  
Vol 44 (4) ◽  
pp. 1173-1178 ◽  
Author(s):  
Viktor Krchňák ◽  
Milan Zaoral
Keyword(s):  
Arginine Vasopressin ◽  
Solid Phase Synthesis ◽  
Solid Phase ◽  
Experimental Conditions ◽  
Phase Synthesis ◽  
Mercaptopropionic Acid ◽  
Better Than

A series of solid-phase syntheses of the protected precursor II of DDAVP was carried out. Experimental conditions were developed under which practically pure II can reproducibly be obtained in yields better than 60%. The protected precursors of DDAVP obtained by liquid- and solid-phase synthesis and DDAVP samples obtained from these precursors were undistinguishable by conventional analytical or pharmacological assays.

ChemInform Abstract: Potent Antagonists of Vasopressin Antidiuretic Activity That Lack the β,β-Cyclopentamethylene-β-mercaptopropionic Acid Substitution at Position 1.

ChemInform ◽  
1987 ◽  
Vol 18 (18) ◽  
Author(s):  
N. C. F. YIM ◽  
M. L. MOORE ◽  
W. F. HUFFMAN ◽  
H. G. BRYAN ◽  
H.-L. CHANG ◽  
...  
Keyword(s):  
Mercaptopropionic Acid ◽  
Antidiuretic Activity
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