ChemInform Abstract: Racemization-Free and Efficient Peptide Synthesis by the Carbodiimide Method Using 1-Hydroxybenzotriazole and Copper(II) Chloride Simultaneously as Additives.

ChemInform ◽  
1988 ◽  
Vol 19 (35) ◽  
Author(s):  
T. MIYAZAWA ◽  
T. OTOMATSU ◽  
Y. FUKUI ◽  
T. YAMADA ◽  
S. KUWATA
Keyword(s):  
Peptide Synthesis ◽  
Carbodiimide Method

Copper(II) chloride as a new, efficient additive suppressing racemization in peptide synthesis by the carbodiimide method

1984 ◽  
Vol 25 (7) ◽  
pp. 771-772 ◽  
Author(s):  
Toshifumi Miyazawa ◽  
Toshihiko Otomatsu ◽  
Takashi Yamada ◽  
Shigeru Kuwata
Keyword(s):  
Peptide Synthesis ◽  
Carbodiimide Method

Effect of copper(II) chloride on suppression of racemization in peptide synthesis by the carbodiimide method

2009 ◽  
Vol 39 (3) ◽  
pp. 237-244 ◽  
Author(s):  
TOSHIFUMI MIYAZAWA ◽  
TOSHIHIKO OTOMATSU ◽  
YOSHIMASA FUKUI ◽  
TAKASHI YAMADA ◽  
SHIGERU KUWATA
Keyword(s):  
Peptide Synthesis ◽  
Carbodiimide Method ◽  
Effect Of Copper

A Strategy for Thioamide Incorporation During Fmoc Solid-Phase Peptide Synthesis with Robust Stereochemical Integrity

2019 ◽  
Author(s):  
luis camacho III ◽  
Bryan J. Lampkin ◽  
Brett VanVeller
Keyword(s):  
Amino Acid ◽  
Functional Groups ◽  
Peptide Synthesis ◽  
Solid Phase ◽  
Solid Phase Peptide Synthesis ◽  
Side Chains ◽  
Amino Acid Side Chains ◽  
Peptide Elongation

We describe a method to protect the sensitive stereochemistry of the thioamide—in analogy to the protection of the functional groups of amino acid side chains—in order to preserve the thioamide moiety during peptide elongation.<br>

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