ChemInform Abstract: Synthetic Studies on Optically Active β-Lactams. Part 2. Asymmetric Synthesis of β-Lactams by (2 + 2)Cyclocondensation Using Heterocyclic Compounds Derived from L-(+)-Tartaric Acid, (S)- or (R)-Glutamic Acid, and (S)-Serine as Chiral

ChemInform ◽  
1990 ◽  
Vol 21 (52) ◽  
Author(s):  
N. IKOTA
2008 ◽  
Vol 80 (4) ◽  
pp. 763-776 ◽  
Author(s):  
Mikiko Sodeoka ◽  
Yoshitaka Hamashima

Highly enantioselective Pd(II)-catalyzed Michael addition, Mannich-type reaction, aldol reaction, fluorination, conjugate addition of amine, and conjugate reduction have been developed. Asymmetric synthesis of biologically interesting heterocyclic compounds, calycotomine, BMS-204352, torcetrapib, and warfarin, was achieved by using these Pd-catalyzed asymmetric reactions as a key step.


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