Synthetic Studies on Optically Active b-Lactams. Asymmetric Synthesis of b-Lactams by the Cyclocondensation Utilizing Chiral Heterocyclic Compounds Derived from L-(+)-Tartaric Acid and (S)-Glutamic Acid

Heterocycles ◽

10.3987/r-1984-10-2227 ◽

1984 ◽

Vol 22 (10) ◽

pp. 2227 ◽

Author(s):

Nobuo Ikota ◽

Akira HAnaki

Keyword(s):

Glutamic Acid ◽

Asymmetric Synthesis ◽

Tartaric Acid ◽

Heterocyclic Compounds ◽

Optically Active ◽

Synthetic Studies

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Synthetic studies on optically active .BETA.-lactams. II. Asymmetric synthesis of .BETA.-lactams by (2+2)cyclocondensation using heterocyclic compounds derived from L-(+)-tartaric acid, (S)- or (R)-glutamic acid, and (S)-serine as chiral auxiliaries.

Chemical and Pharmaceutical Bulletin ◽

10.1248/cpb.38.1601 ◽

1990 ◽

Vol 38 (6) ◽

pp. 1601-1608 ◽

Author(s):

Nobuo IKOTA

Keyword(s):

Glutamic Acid ◽

Asymmetric Synthesis ◽

Tartaric Acid ◽

Heterocyclic Compounds ◽

Optically Active ◽

Chiral Auxiliaries ◽

Beta Lactams ◽

Synthetic Studies

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ChemInform Abstract: SYNTHETIC STUDIES ON OPTICALLY ACTIVE β-LACTAMS. ASYMMETRIC SYNTHESIS OF β-LACTAMS BY THE CYCLOCONDENSATION UTILIZING CHIRAL HETEROCYCLIC COMPOUNDS DERIVED FROM L-(+)-TARTARIC ACID AND (S)-GLUTAMIC ACID

Chemischer Informationsdienst ◽

10.1002/chin.198518087 ◽

1985 ◽

Vol 16 (18) ◽

Author(s):

N. IKOTA ◽

A. HANAKI

Keyword(s):

Glutamic Acid ◽

Asymmetric Synthesis ◽

Tartaric Acid ◽

Heterocyclic Compounds ◽

Optically Active ◽

Synthetic Studies

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ChemInform Abstract: Synthetic Studies on Optically Active β-Lactams. Part 2. Asymmetric Synthesis of β-Lactams by (2 + 2)Cyclocondensation Using Heterocyclic Compounds Derived from L-(+)-Tartaric Acid, (S)- or (R)-Glutamic Acid, and (S)-Serine as Chiral

10.1002/chin.199052150 ◽

1990 ◽

Vol 21 (52) ◽

Author(s):

N. IKOTA

Keyword(s):

Glutamic Acid ◽

Asymmetric Synthesis ◽

Tartaric Acid ◽

Heterocyclic Compounds ◽

Optically Active ◽

Synthetic Studies

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ChemInform Abstract: SYNTHETIC STUDIES ON OPTICALLY ACTIVE EPOXYTERPENES FROM L-GLUTAMIC ACID. II. YNTHESES OF R-(+)-10,11-EPOXYFARNESOL, R-(+)-, AND S-(-)-SQUALENE-2,3-OXIDE

Chemischer Informationsdienst ◽

10.1002/chin.197642363 ◽

1976 ◽

Vol 7 (42) ◽

pp. no-no

Author(s):

S. YAMADA ◽

N. OH-HASHI ◽

K. ACHIWA

Keyword(s):

Glutamic Acid ◽

Optically Active ◽

Synthetic Studies

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ChemInform Abstract: Asymmetric Synthesis of β-Lactams Using Chiral Five-Membered Heterocyclic Compounds Derived from (+)-Tartaric Acid and L-Amino Acids.

Chemischer Informationsdienst ◽

10.1002/chin.198439149 ◽

1984 ◽

Vol 15 (39) ◽

Author(s):

N. IKOTA ◽

A. HANAKI

Keyword(s):

Amino Acids ◽

Asymmetric Synthesis ◽

Tartaric Acid ◽

Heterocyclic Compounds

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Synthetic studies on optically active epoxyterpenes from L-glutamic acid-I syntheses of R-(+)-epoxygeraniol, R-(+)-marmin and R-(+)-epoxyaurapten

Tetrahedron Letters ◽

10.1016/s0040-4039(00)78146-9 ◽

1976 ◽

Vol 17 (29) ◽

pp. 2557-2560 ◽

Author(s):

Shun-ichi Yamada ◽

Naohito Oh-hashi ◽

Kazuo Achiwa

Keyword(s):

Glutamic Acid ◽

Optically Active ◽

Synthetic Studies

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ChemInform Abstract: SYNTHETIC STUDIES ON OPTICALLY ACTIVE EPOXYTERPENES FROM L-GLUTAMIC ACID. I. SYNTHESES OF R-(+)-EPOXYGERANIOL, R-(+)-MARMIN AND R-(+)-EPOXYAURAPTEN

Chemischer Informationsdienst ◽

10.1002/chin.197642362 ◽

1976 ◽

Vol 7 (42) ◽

pp. no-no

Author(s):

S. YAMADA ◽

N. OH-HASHI ◽

K. ACHIWA

Keyword(s):

Glutamic Acid ◽

Optically Active ◽

Synthetic Studies

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Asymmetric Synthesis of b-Lactams Using Chiral Five-membered Heterocyclic Compounds Derived from (+)-Tartaric Acid and L-Amino Acids

Heterocycles ◽

10.3987/s-1984-02-0418 ◽

1984 ◽

Vol 21 (2) ◽

pp. 418 ◽

Author(s):

Nobuo Ikota ◽

Akira Hanaki

Keyword(s):

Amino Acids ◽

Asymmetric Synthesis ◽

Tartaric Acid ◽

Heterocyclic Compounds

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Synthetic studies on optically active epoxyterpenes from L-glutamic acid-II syntheses of R-(+)-10,11-epoxyfarnesol and R-(+), S-(−)-squalene-2,3-oxide

Tetrahedron Letters ◽

10.1016/s0040-4039(00)78147-0 ◽

1976 ◽

Vol 17 (29) ◽

pp. 2561-2564 ◽

Author(s):

Shun-ichi Yamada ◽

Naohito Oh-hashi ◽

Kazuo Achiwa

Keyword(s):

Glutamic Acid ◽

Optically Active ◽

Synthetic Studies

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Synthesis of optically active heterocyclic compounds using Pd-catalyzed asymmetric reactions as a key step

Pure and Applied Chemistry ◽

10.1351/pac200880040763 ◽

2008 ◽

Vol 80 (4) ◽

pp. 763-776 ◽

Author(s):

Mikiko Sodeoka ◽

Yoshitaka Hamashima

Keyword(s):

Asymmetric Synthesis ◽

Michael Addition ◽

Heterocyclic Compounds ◽

Aldol Reaction ◽

Conjugate Addition ◽

Optically Active ◽

Asymmetric Reactions ◽

Type Reaction ◽

Conjugate Reduction

Highly enantioselective Pd(II)-catalyzed Michael addition, Mannich-type reaction, aldol reaction, fluorination, conjugate addition of amine, and conjugate reduction have been developed. Asymmetric synthesis of biologically interesting heterocyclic compounds, calycotomine, BMS-204352, torcetrapib, and warfarin, was achieved by using these Pd-catalyzed asymmetric reactions as a key step.

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