Synthesis of a new series of (5-bromo-5-nitro-2-oxido-1,3,2-
dioxaphosphinan-2-yl)amino acid esters (3a-l) was accomplished via a two step
process, which involves the prior preparation of the monochloride
intermediate (2) and its subsequent reaction with the amino acid esters in
dry tetrahydrofuran in the presence of triethylamine at reflux temperature.
The title compounds (3a-l) structures were established by analytical, IR,
1H-, 13C- and 31P-NMR, and mass spectral data. They exhibited significant
antibacterial and antifungal activity.
Chromatographic Enantiomer Separation and Determination of Optical Purity for α-Amino Acid Esters as 9-Anthraldimine Derivatives Using Polysaccharide Based Chiral Columns