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Author(s):  
Shinji Kamisuki ◽  
Hisanobu Shibasaki ◽  
Koudai Ashikawa ◽  
Kazuki Kanno ◽  
Koichi Watashi ◽  
...  

Author(s):  
Elizalde L. Piol ◽  
◽  
Luisito Lolong Lacatan ◽  
Jaime P. Pulumbarit

The use of Linear Regression in predicting enrolment has been shown to be beneficial, although it varies with various datasets and attributes; varying weights of the correlation of the attributes can be discarded if they do not impact the prediction. Data collecting had grown since prior investigations, resulting in a more complicated dataset with many varieties. As a result of the data being created by multiple clerks, cleaning and combining proved tough; nonetheless, the fundamental parameters remain intact. Different algorithms were examined but Linear Regression obtained the highest accuracy with a 12.398 percentage for the absolute error and a root mean squared of 26.936 to create a tangible model to anticipate the enrolment of Region IVA CALABARZON in the Philippines. This demonstrates that it was 2.067 percentage points more than the prior research.


2022 ◽  
pp. annrheumdis-2021-221477
Author(s):  
Denis Mongin ◽  
Kim Lauper ◽  
Axel Finckh ◽  
Thomas Frisell ◽  
Delphine Sophie Courvoisier

ObjectivesTo assess the performance of statistical methods used to compare the effectiveness between drugs in an observational setting in the presence of attrition.MethodsIn this simulation study, we compared the estimations of low disease activity (LDA) at 1 year produced by complete case analysis (CC), last observation carried forward (LOCF), LUNDEX, non-responder imputation (NRI), inverse probability weighting (IPW) and multiple imputations of the outcome. All methods were adjusted for confounders. The reasons to stop the treatments were included in the multiple imputation method (confounder-adjusted response rate with attrition correction, CARRAC) and were either included (IPW2) or not (IPW1) in the IPW method. A realistic simulation data set was generated from a real-world data collection. The amount of missing data caused by attrition and its dependence on the ‘true’ value of the data missing were varied to assess the robustness of each method to these changes.ResultsLUNDEX and NRI strongly underestimated the absolute LDA difference between two treatments, and their estimates were highly sensitive to the amount of attrition. IPW1 and CC overestimated the absolute LDA difference between the two treatments and the overestimation increased with increasing attrition or when missingness depended on disease activity at 1 year. IPW2 and CARRAC produced unbiased estimations, but IPW2 had a greater sensitivity to the missing pattern of data and the amount of attrition than CARRAC.ConclusionsOnly multiple imputation and IPW2, which considered both confounding and treatment cessation reasons, produced accurate comparative effectiveness estimates.


2022 ◽  
Vol 17 (4) ◽  
pp. 27-40
Author(s):  
T. G. Korneeva

The article raises the question of understanding the principle of tawhid in the Isma‘ili philosophical discourse. Isma‘ili philosophers defended the absolute transcendence of God and His indescribability. The article describes the understanding of the one and only God in Isma‘ilism, analyzes the problem of the relationship between the One and the multiple within the paradigmatic pairs of Arab-Muslim philosophy ‒ “explicit‒hidden” and “basic‒branch”. It is impossible to call God the Original, otherwise it will be necessary to recognize that He is dependent and conditioned by His consequence, and this detracts from Him. God, according to the ideas of Ismailism, has only one “true” attribute — huwiyya, which forms the required nominal multiplicity and “transition” from the transcendent God to the cognizable plural world. It is the huwiyya of God that gives the impetus for the appearance of the First Cause — the command of God “Be!”, which is also its own consequence. Combining cause and eff ect, the command of God has absolute completeness. The reader is also off ered for the fi rst time in Russian a commented translation of an excerpt from the treatise of the Ismaili philosopher of the 11th century Nasir Khusraw “Six chapters” (Shish fasl) — Chapter “On the knowledge of tawhid”.


2022 ◽  
pp. 019145372110668
Author(s):  
Kirk Turner ◽  
Caitlyn Lesiuk

In Alain Badiou’s most recent work, L’immanence des vérités ( The Immanence of Truths), psychoanalyst Jacques Lacan once again figures peripherally but saliently. What is their specific relation in this text, however? We argue that Badiou responds here to the problem raised precisely by the Lacanian subject, situated as it is between the radical subjectivity of the symptom and the possibility of formalization. In L’immanence, he introduces the term ‘absoluteness’ to secure truths against both relativism and transcendental construction. We show that in drawing on Lacan to establish an understanding of the absolute, Badiou highlights the implicit tension between psychoanalysis and philosophy. We treat central cross-currents – truths, knowledge, the event and love – to help reveal the specific character of their confluence in this third book of Badiou’s trilogy. Although he stresses the unity of his and Lacan’s efforts, the impossible Real marking their divisions also invariably emerges the closer one investigates.


2022 ◽  
Vol 32 (3) ◽  
Author(s):  
Mingming Cao ◽  
José María Martell ◽  
Andrea Olivo

AbstractIn nice environments, such as Lipschitz or chord-arc domains, it is well-known that the solvability of the Dirichlet problem for an elliptic operator in $$L^p$$ L p , for some finite p, is equivalent to the fact that the associated elliptic measure belongs to the Muckenhoupt class $$A_\infty $$ A ∞ . In turn, any of these conditions occurs if and only if the gradient of every bounded null solution satisfies a Carleson measure estimate. This has been recently extended to much rougher settings such as those of 1-sided chord-arc domains, that is, sets which are quantitatively open and connected with a boundary which is Ahlfors–David regular. In this paper, we work in the same environment and consider a qualitative analog of the latter equivalence showing that one can characterize the absolute continuity of the surface measure with respect to the elliptic measure in terms of the finiteness almost everywhere of the truncated conical square function for any bounded null solution. As a consequence of our main result particularized to the Laplace operator and some previous results, we show that the boundary of the domain is rectifiable if and only if the truncated conical square function is finite almost everywhere for any bounded harmonic function. In addition, we obtain that for two given elliptic operators $$L_1$$ L 1 and $$L_2$$ L 2 , the absolute continuity of the surface measure with respect to the elliptic measure of $$L_1$$ L 1 is equivalent to the same property for $$L_2$$ L 2 provided the disagreement of the coefficients satisfy some quadratic estimate in truncated cones for almost everywhere vertex. Finally, for the case on which $$L_2$$ L 2 is either the transpose of $$L_1$$ L 1 or its symmetric part we show the equivalence of the corresponding absolute continuity upon assuming that the antisymmetric part of the coefficients has some controlled oscillation in truncated cones for almost every vertex.


2022 ◽  
Vol 12 ◽  
Author(s):  
Sergio Murolo ◽  
Marwa Moumni ◽  
Valeria Mancini ◽  
Mohamed Bechir Allagui ◽  
Lucia Landi ◽  
...  

Stagonosporopsis cucurbitacearum is an important seedborne pathogen of squash (Cucurbita maxima). The aim of our work was to develop a rapid and sensitive diagnostic tool for detection and quantification of S. cucurbitacearum in squash seed samples, to be compared with blotter analysis, that is the current official seed test. In blotter analysis, 29 of 31 seed samples were identified as infected, with contamination from 1.5 to 65.4%. A new set of primers (DB1F/R) was validated in silico and in conventional, quantitative real-time PCR (qPCR) and droplet digital (dd) PCR. The limit of detection of S. cucurbitacearum DNA for conventional PCR was ∼1.82 × 10–2 ng, with 17 of 19 seed samples positive. The limit of detection for ddPCR was 3.6 × 10–3 ng, which corresponded to 0.2 copies/μl. Detection carried out with artificial samples revealed no interference in the absolute quantification when the seed samples were diluted to 20 ng. All seed samples that showed S. cucurbitacearum contamination in the blotter analysis were highly correlated with the absolute quantification of S. cucurbitacearum DNA (copies/μl) in ddPCR (R2 = 0.986; p ≤ 0.01). Our ddPCR protocol provided rapid detection and absolute quantification of S. cucurbitacearum, offering a useful support to the standard procedure.


2022 ◽  
pp. 036354652110678
Author(s):  
Joseph E. Manzi ◽  
Brittany Dowling ◽  
Zhaorui Wang ◽  
Andrew Luzzi ◽  
Ryan Thacher ◽  
...  

Background: Biomechanical predictors of pitching accuracy are underevaluated in baseball research. It is unclear how pitchers with higher accuracy differ in terms of kinematics and upper extremity kinetics. Purpose: To differentiate high- and low-accuracy professional pitchers by full-body kinematic and upper extremity kinetic parameters. Study Design: Descriptive laboratory study. Methods: In total, 121 professional baseball pitchers threw 8 to 12 fastballs while assessed with motion-capture technology (480 Hz). Pitchers were divided into high-accuracy (n = 33), moderate-accuracy (n = 52), and low-accuracy (n = 36) groups based on the absolute center deviation of each pitcher’s average pitch to the center of the pitching chart by greater or less than 0.5 SD from the mean, respectively. The 95% confidence ellipses with comparisons of major and minor radii and pitching probability density grids were constructed. Analysis of variance was used to compare kinematic and kinetic values between groups. Results: The absolute center deviation (14.5% ± 6.7% vs 33.5% ± 3.7% grid width; P < .001) was significantly lower in the high-accuracy compared with the low-accuracy group, with no significant difference in ball velocity (38.0 ± 1.7 vs 38.5 ± 2.0 m/s; P = .222). Lead knee flexion at ball release (30.6°± 17.8° vs 40.1°± 16.3°; P = .023) was significantly less for the high-accuracy pitchers. Peak normalized shoulder internal rotation torque (5.5% ± 1.0% vs 4.9% ± 0.7% body weight [BW] × body height [BH]; P = .008), normalized elbow varus torque (5.4% ± 1.0% vs 4.8% ± 0.7% BW × BH; P = .008), and normalized elbow medial force (42.9% ± 7.3% vs 38.6% ± 6.2% BW; P = .024) were significantly greater for the low-accuracy group compared with the high-accuracy group. Conclusion: Professional pitchers with increased accuracy experienced decreased throwing arm kinetics. These pitchers had increased lead knee extension at later stages of the pitch, potentially providing more stable engagement with the ground and transference of kinetic energy to the upper extremities. Professional pitchers can consider increasing lead knee extension at the final stages of the pitch to improve the accuracy of their throws and mitigate elbow varus torque. Clinical Relevance: Increased elbow varus torque, shoulder internal rotation torque, and elbow medial force in less accurate pitchers may contribute to increased injury risk in this group.


2022 ◽  
Vol 11 ◽  
Author(s):  
Yu Fan ◽  
Yelin Mulati ◽  
Lingyun Zhai ◽  
Yuke Chen ◽  
Yu Wang ◽  
...  

BackgroundSeveral active surveillance (AS) criteria have been established to screen insignificant prostate cancer (insigPCa, defined as organ confined, low grade and small volume tumors confirmed by postoperative pathology). However, their comparative diagnostic performance varies. The aim of this study was to compare the diagnostic accuracy of contemporary AS criteria and validate the absolute diagnostic odds ratio (DOR) of optimal AS criteria.MethodsFirst, we searched Pubmed and performed a Bayesian network meta-analysis (NMA) to compare the diagnostic accuracy of contemporary AS criteria and obtained a relative ranking. Then, we searched Pubmed again to perform another meta-analysis to validate the absolute DOR of the top-ranked AS criteria derived from the NMA with two endpoints: insigPCa and favorable disease (defined as organ confined, low grade tumors). Subgroup and meta-regression analyses were conducted to identify any potential heterogeneity in the results. Publication bias was evaluated.ResultsSeven eligible retrospective studies with 3,336 participants were identified for the NMA. The diagnostic accuracy of AS criteria ranked from best to worst, was as follows: Epstein Criteria (EC), Yonsei criteria, Prostate Cancer Research International: Active Surveillance (PRIAS), University of Miami (UM), University of California-San Francisco (UCSF), Memorial Sloan-Kettering Cancer Center (MSKCC), and University of Toronto (UT). I2 = 50.5%, and sensitivity analysis with different insigPCa definitions supported the robustness of the results. In the subsequent meta-analysis of DOR of EC, insigPCa and favorable disease were identified as endpoints in ten and twenty-two studies, respectively. The pooled DOR for insigPCa and favorable disease were 0.44 (95%CI, 0.31–0.58) and 0.66 (95%CI, 0.61–0.71), respectively. According to a subgroup analysis, the DOR for favorable disease was significantly higher in US institutions than that in other regions. No significant heterogeneity or evidence of publication bias was identified.ConclusionsAmong the seven AS criteria evaluated in this study, EC was optimal for positively identifying insigPCa patients. The pooled diagnostic accuracy of EC was 0.44 for insigPCa and 0.66 when a more liberal endpoint, favorable disease, was used.Systematic Review Registration[https://www.crd.york.ac.uk/prospero/], PROSPERO [CRD42020157048].


Author(s):  
João Ribeiro ◽  
Petrus Gantois ◽  
Vitor Moreira ◽  
Francisco Miranda ◽  
Nuno Romano ◽  
...  

AbstractThe aim of the present study was to determine the creatine kinase reference limits for professional soccer players based on their own normal post-match response. The creatine kinase concentration was analyzed in response to official matches in 25 players throughout a 3-year period. Samples were obtained between 36–43 hours following 70 professional soccer matches and corresponded to 19.1±12.1 [range: 6–49] samples per player. Absolute reference limits were calculated as 2.5th and 97.5th percentile of the samples collected. Creatine kinase values were also represented as a percentage change from the individual’s season mean and represented by 90th, 95th and 97.5th percentiles. The absolute reference limits for creatine kinase concentration calculated as 97.5th and 2.5th percentiles were 1480 U.L−1 and 115.8 U.L−1, respectively. The percentage change from the individual’s season mean was 97.45±35.92% and players were in the 90th, 95th and 97.5th percentiles when the percentages of these differences were 50.01, 66.7, and 71.34% higher than player’s season mean response, respectively. The data allowed us to determine whether the creatine kinase response is typical or if it is indicative of a higher than normal creatine kinase elevation and could be used as a practical guide for detection of muscle overload, following professional soccer match-play.


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