ChemInform Abstract: New Synthetic Technology for the Construction of 9-Membered Ring Cyclic Ethers. Construction of the EFGH Ring Skeleton of Brevetoxin A.

ChemInform ◽  
2010 ◽  
Vol 28 (50) ◽  
pp. no-no
Author(s):  
K. C. NICOLAOU ◽  
Z. YANG ◽  
M. OUELLETTE ◽  
G.-Q. SHI ◽  
P. GAERTNER ◽  
...  
Keyword(s):  
Membered Ring ◽  
Cyclic Ethers ◽  
Brevetoxin A

New Synthetic Technology for the Construction of 9-Membered Ring Cyclic Ethers. Construction of the EFGH Ring Skeleton of Brevetoxin A

1997 ◽  
Vol 119 (34) ◽  
pp. 8105-8106 ◽  
Author(s):  
K. C. Nicolaou ◽  
Z. Yang ◽  
M. Ouellette ◽  
G.-Q. Shi ◽  
P. Gärtner ◽  
...  
Keyword(s):  
Membered Ring ◽  
Cyclic Ethers ◽  
Brevetoxin A

An Alternate Energy-Conserved Pathway for the Morita-Baylis-Hillman (MBH) Reaction

2020 ◽  
Author(s):  
Veejendra Yadav
Keyword(s):  
Proton Transfer ◽  
Transition State ◽  
Lower Energy ◽  
Aldol Reaction ◽  
Membered Ring ◽  
Ammonium Ion ◽  
Alternate Energy ◽  
Ring Transition State ◽  
Mbh Reaction

An new overall lower energy pathway for the amine-catalysed Morita-Baylis-Hillman reaction is proposed from computations at the M06-2X/6-311++G(d,p) level. The pathway involves proton-transfer from the ammonium ion to the alkoxide formed from the aldol reaction through a seven-membered ring transition state (TS) structure followed by highly exothermic Hofmann<i> </i>elimination through a five-membered ring TS structure to form the product and also release the catalyst to carry on with the process all over again.

An Alternate Energy-Conserved Pathway for the Morita-Baylis-Hillman (MBH) Reaction

2020 ◽  
Author(s):  
Veejendra Yadav
Keyword(s):  
Proton Transfer ◽  
Transition State ◽  
Lower Energy ◽  
Aldol Reaction ◽  
Membered Ring ◽  
Ammonium Ion ◽  
Alternate Energy ◽  
Ring Transition State ◽  
Mbh Reaction

An new overall lower energy pathway for the amine-catalysed Morita-Baylis-Hillman reaction is proposed from computations at the M06-2X/6-311++G(d,p) level. The pathway involves proton-transfer from the ammonium ion to the alkoxide formed from the aldol reaction through a seven-membered ring transition state (TS) structure followed by highly exothermic Hofmann<i> </i>elimination through a five-membered ring TS structure to form the product and also release the catalyst to carry on with the process all over again.

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