An Alternate Energy-Conserved Pathway for the Morita-Baylis-Hillman (MBH) Reaction
Keyword(s):
An new overall lower energy pathway for the amine-catalysed Morita-Baylis-Hillman reaction is proposed from computations at the M06-2X/6-311++G(d,p) level. The pathway involves proton-transfer from the ammonium ion to the alkoxide formed from the aldol reaction through a seven-membered ring transition state (TS) structure followed by highly exothermic Hofmann<i> </i>elimination through a five-membered ring TS structure to form the product and also release the catalyst to carry on with the process all over again.
2015 ◽
Vol 17
(35)
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pp. 22529-22532
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Keyword(s):
2019 ◽
Vol 6
(10)
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pp. 2944-2952
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Keyword(s):
2020 ◽
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