ChemInform Abstract: Synthesis and Anorectic Activity of 2H-4,6-Dimethyl-2- [(4-phenylpiperazin-1-yl)methyl]-3-oxo-2,3-dihydroisothiazolo [5,4-b]pyridine.

ChemInform ◽  
2010 ◽  
Vol 29 (21) ◽  
pp. no-no
Author(s):  
W. MALINKA ◽  
M. RUTKOWSKA
Keyword(s):  
Anorectic Activity

Synthesis and biological properties of cholecystokinin heptapeptide analogues containing D- and L-forms of tert-leucine or neopentylglycine in position 5

1991 ◽  
Vol 56 (10) ◽  
pp. 2209-2217 ◽  
Author(s):  
Jan Hlaváček ◽  
Jana Pírková ◽  
Jan Pospíšek ◽  
Jiřina Slaninová ◽  
Lenka Maletínská
Keyword(s):  
Gall Bladder ◽  
Solid Phase ◽  
Biological Activities ◽  
Biological Properties ◽  
Phase Synthesis ◽  
Structural Modifications ◽  
Bladder Contraction ◽  
Anorectic Effect ◽  
Carboxy Terminal ◽  
Anorectic Activity

Using solution or solid-phase synthesis we prepared the cholecystokinin fragment Boc-CCK-7 (Boc-Tyr-(SO3-.Na+)-Met-Gly-Trp-Met-Asp-PheNH2) and its four analogues in which the methionine moiety (Met) in the carboxy-terminal part is replaced by tert-leucine (Tle) or neopentylglycine (Neo) residue or D-enantiomers of these non-coded amino acids. These structural modifications led to reduction of the studied biological activities (gall bladder contraction, anorectic activity, analgetic and sedation activity) of all prepared analogues except Boc[Neo5]-CCK-7 which, being less analgetically active, retains full gall bladder and sedation activity of CCK-8. Moreover, its anorectic activity is substantially higher (400%). This analogue is very interesting particularly for its selectively increased (4x) anorectic effect compared with that of CCK-8.

Anorectic activity of NG-nitro-L-arginine, an inhibitor of brain nitric oxide synthase, in obese Zucker rats

1993 ◽  
Vol 230 (1) ◽  
pp. 125-128 ◽  
Author(s):  
Francesco Squadrito ◽  
Gioacchino Calapai ◽  
Domenico Cucinotta ◽  
Domenica Altavilla ◽  
Basilia Zingarelli ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Nitric Oxide Synthase ◽  
Zucker Rats ◽  
Obese Zucker Rats ◽  
Oxide Synthase ◽  
Brain Nitric Oxide ◽  
Anorectic Activity

Evidence that central 5-HT2 receptors do not play an important role in the anorectic activity of d-fenfluramine in the rat

1989 ◽  
Vol 28 (5) ◽  
pp. 465-469 ◽  
Author(s):  
R. Samanin ◽  
T. Mennini ◽  
C. Bendotti ◽  
D. Barone ◽  
S. Caccia ◽  
...  
Keyword(s):  
Anorectic Activity

A Novel Inhibitor of Gamma-Aminobutyrate Aminotransferase with Anorectic Activity

1982 ◽  
Vol 39 (1) ◽  
pp. 271-273 ◽  
Author(s):  
H. L. White ◽  
J. L. Howard ◽  
B. R. Cooper ◽  
F. E. Soroko ◽  
J. D. McDermed ◽  
...  
Keyword(s):  
Aminobutyrate Aminotransferase ◽  
Anorectic Activity

5-HT2C receptor agonists with potential anorectic activity

2008 ◽  
Vol 31 (8) ◽  
pp. 989-994 ◽  
Author(s):  
Goo Yoon ◽  
Hee Jin Jeong ◽  
Jeong Ju Kim ◽  
Seung Hoon Cheon
Keyword(s):  
Receptor Agonists ◽  
Anorectic Activity
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