ChemInform Abstract: Iron-Catalyzed Cross-Coupling Reactions of Alkyl-Grignard Reagents with Aryl Chlorides, Tosylates, and Triflates.

ChemInform ◽  
2010 ◽  
Vol 33 (27) ◽  
pp. no-no
Author(s):  
Alois Fuerstner ◽  
Andreas Leitner
Keyword(s):  
Cross Coupling ◽  
Grignard Reagents ◽  
Coupling Reactions ◽  
Aryl Chlorides ◽  
Cross Coupling Reactions

scholarly journals Iron-Catalyzed Cross-Coupling Reactions of Alkyl Grignards with Aryl Chlorobenzenesulfonates

Molecules ◽  
2021 ◽  
Vol 26 (19) ◽  
pp. 5895
Author(s):  
Elwira Bisz
Keyword(s):  
Organic Chemistry ◽  
Catalytic System ◽  
Cross Coupling ◽  
Environmentally Benign ◽  
Grignard Reagents ◽  
Coupling Reactions ◽  
Aryl Chlorides ◽  
Cross Coupling Reactions ◽  
Bioactive Properties ◽  
Synthetic Intermediates

Aryl sulfonate esters are versatile synthetic intermediates in organic chemistry as well as attractive architectures due to their bioactive properties. Herein, we report the synthesis of alkyl-substituted benzenesulfonate esters by iron-catalyzed C(sp2)–C(sp3) cross-coupling of Grignard reagents with aryl chlorides. The method operates using an environmentally benign and sustainable iron catalytic system, employing benign urea ligands. A broad range of chlorobenzenesulfonates as well as challenging alkyl organometallics containing β-hydrogens are compatible with these conditions, affording alkylated products in high to excellent yields. The study reveals that aryl sulfonate esters are the most reactive activating groups for iron-catalyzed alkylative C(sp2)–C(sp3) cross-coupling of aryl chlorides with Grignard reagents.

Novel cross-coupling reactions between organotellurides and Grignard reagents employing a MnCl2/CuI catalytic system

2012 ◽  
Vol 53 (28) ◽  
pp. 3556-3559 ◽  
Author(s):  
Marcio S. Silva ◽  
Renan S. Ferrarini ◽  
Bruno A. Sousa ◽  
Fabiano T. Toledo ◽  
João V. Comasseto ◽  
...  
Keyword(s):  
Catalytic System ◽  
Cross Coupling ◽  
Grignard Reagents ◽  
Coupling Reactions ◽  
Cross Coupling Reactions

scholarly journals Stereospecific Nickel-Catalyzed Cross-Coupling Reactions of Alkyl Grignard Reagents and Identification of Selective Anti-Breast-Cancer Agents

2014 ◽  
Vol 126 (9) ◽  
pp. 2454-2459 ◽  
Author(s):  
Ivelina M. Yonova ◽  
A. George Johnson ◽  
Charlotte A. Osborne ◽  
Curtis E. Moore ◽  
Naomi S. Morrissette ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cross Coupling ◽  
Grignard Reagents ◽  
Coupling Reactions ◽  
Cross Coupling Reactions

scholarly journals Stereospecific Pd-Catalyzed Cross-Coupling Reactions of Secondary Alkylboron Nucleophiles and Aryl Chlorides

2014 ◽  
Vol 136 (40) ◽  
pp. 14027-14030 ◽  
Author(s):  
Ling Li ◽  
Shibin Zhao ◽  
Amruta Joshi-Pangu ◽  
Mohamed Diane ◽  
Mark R. Biscoe
Keyword(s):  
Cross Coupling ◽  
Coupling Reactions ◽  
Aryl Chlorides ◽  
Cross Coupling Reactions
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