ChemInform Abstract: Metal-Free Michael-Addition-Initiated Three-Component Reaction for the Regioselective Synthesis of Highly Functionalized Pyridines: Scope, Mechanistic Investigations and Applications.

ChemInform ◽  
2013 ◽  
Vol 44 (47) ◽  
pp. no-no
Author(s):  
Christophe Allais ◽  
Frederic Lieby-Muller ◽  
Jean Rodriguez ◽  
Thierry Constantieux
Keyword(s):  
Michael Addition ◽  
Regioselective Synthesis ◽  
Metal Free ◽  
Three Component Reaction ◽  
Mechanistic Investigations

A Metal-Free Three-Component Reaction for the Regioselective Synthesis of 1,4,5-Trisubstituted 1,2,3-Triazoles

2014 ◽  
Vol 126 (38) ◽  
pp. 10319-10323 ◽  
Author(s):  
Joice Thomas ◽  
Jubi John ◽  
Nikita Parekh ◽  
Wim Dehaen
Keyword(s):  
Regioselective Synthesis ◽  
Metal Free ◽  
Three Component Reaction

scholarly journals Transition metal-free domino acyl substitution/Michael addition of alkenyl Grignard reagents to lactam esters: synthesis of lactam-bearing homoallylic ketones

RSC Advances ◽  
2020 ◽  
Vol 10 (38) ◽  
pp. 22454-22459 ◽  
Author(s):  
Abdikani Omar Farah ◽  
Muhannad Rabah ◽  
Timothy K. Beng
Keyword(s):  
Transition Metal ◽  
Michael Addition ◽  
Regioselective Synthesis ◽  
Grignard Reagents ◽  
Metal Free

A solvent-controlled and heteroatom-dictated protocol for the transition metal-free addition of alkenyl Grignard reagents to lactam esters has been developed, leading to the chemo- and regioselective synthesis of lactam-tethered homoallylic ketones.

Visible Light-Induced Sulfonylation/Arylation of Styrenes in a Double Radical Three-Component Photoredox Reaction

2019 ◽  
Author(s):  
Benjamin Lipp ◽  
Lisa Marie Kammer ◽  
Murat Kucukdisli ◽  
Adriana Luque ◽  
Jonas Kühlborn ◽  
...  
Keyword(s):  
Visible Light ◽  
Radical Formation ◽  
Three Component Reaction ◽  
Broad Variety ◽  
Styrene Derivatives ◽  
Mechanistic Investigations

Simultaneous sulfonylation/arylation of styrene derivatives is achieved in a photoredox-catalyzed three-component reaction using visible light. A broad variety of difunctionalized products is accessible in mostly excellent yields and high diastereoselectivity. The developed reaction is scalable and suitable for the modification of styrene-functionalized biomolecules. Mechanistic investigations suggest the transformation to be operating through a designed sequence of radical formation and radical combination.<br>

Visible-light-promoted sulfonylation of thiols with aryldiazonium and sodium metabisulphite leading to unsymmetrical thiosulfonates

2021 ◽  
Author(s):  
Yu-Fen Lv ◽  
Jinyun Luo ◽  
Yuchuan Ma ◽  
Qi Dong ◽  
Lin He
Keyword(s):  
Visible Light ◽  
Room Temperature ◽  
Metal Free ◽  
Sodium Metabisulphite ◽  
Three Component Reaction

A new visible-light-mediated protocol has been proposed for the synthesis of thiosulfonates via metal-free sulfonylation of thiols with aryldiazonium and sodium metabisulphite at room temperature. This mild three-component reaction, simply...

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