Electrochemical Radical C(sp3)-H Arylation of Xanthenes with Electron-Rich Arenes

C(sp3)-H arylation has recently emerged as a powerful straegy for complex organic molecules synthesis through a new carbon-carbon bond formation. We herein describe an efficient electrochemical C(sp3)-H arylation of xanthenes...

RhIII-catalyzed heteroarylation of N-2,6-difluorophenyl arylamides with heteroaryl boronate esters

Herein, an efficient strategy to aryl-heteroaryl formation via RhIII-catalyzed ortho-C(sp2)−H heteroarylation of (hetero)arenes with heterocyclic boronates using a readily removable N-2,6-difluorophenyl arylamides directing group has been disclosed. A variety of...

Photoinduced C-H monofluoroalkenylation with gem-difluoroalkenes through hydrogen atom transfer in batch and flow

Direct monofluoroalkenylation of C-H bonds are straightforward approaches for accessing multisubstituted monofluoroalkenes. However, general methods for the monofluoroalkenylation of C(sp3)-H bonds remain challenges. Here we report the development of a...

Direct Synthesis β-Acyloxy Aldehydes from Linear Allylic Esters Using O2 as Sole Oxidant

A simple and practical preparation of β-O substituted aldehydes directly from linear allylic esters is developed. Using bis(benzonitrile)palladium chloride as the catalyst and O2 as sole oxidant, the tandem isomerization-...

Iridium(III)-Catalyzed Two-Fold C−H Alkylation of BINOLs with Allyl Alcohols

Ir(III)-catalyzed C−H alkylation of BINOL units has been well examined by allyl alcohols as coupling partners. Under the advantage of pyridine guiding group, the efficient protocol allows the rapid synthesis...

Pyrylium Salts Acting as Both Energy Transfer and Electron Transfer Photocatalysts for E→Z Isomerization of Activated Alkenes and Cyclization of Cinnamic or Biaryl Carboxylic Acids

2,4,6-Triarylpyrylium salts are stable, easily available and cheap. However, only their elec-tron transfer oxidation ability was explored. We herein report that they could perform both energy transfer and electron transfer...

Room temperature synthesis of perylene diimides facilitated by high amic acid solubility

A novel protocol for the synthesis of perylene diimides (PDIs), by reacting perylene dianhydride (PDA) with aliphatic amines is reported. Full conversions were obtained at temperatures between 20 and 60˚C,...

Cyanation and Cyanomethylation of Trimethylammonium Salts via Electrochemical Cleavage of C–N Bonds

We have developed a practical and mild electrochemical protocol for cyanation and cyanomethylation of trimethylammonium salts through a pathway involving C−N bond cleavage without the need for externally stoichiometric reducing...

S-Triggered Schmidt-type Rearrangement of Vinyl Azides to Access N-Aryl-(trifluoromethylsulfinyl)acetamides

A novel S-induced Schmidt-type rearrangement of vinyl azides with CF3SO2Na is reported, which is mediated by triphosgene (BTC) under mild reaction conditions. A wide range of N-arylated 2-(trifluoromethylsulfinyl)acetamieds, for the...