Transition metal-free domino acyl substitution/Michael addition of alkenyl Grignard reagents to lactam esters: synthesis of lactam-bearing homoallylic ketones

RSC Advances ◽

10.1039/d0ra03885g ◽

2020 ◽

Vol 10 (38) ◽

pp. 22454-22459 ◽

Author(s):

Abdikani Omar Farah ◽

Muhannad Rabah ◽

Timothy K. Beng

Keyword(s):

Transition Metal ◽

Michael Addition ◽

Regioselective Synthesis ◽

Grignard Reagents ◽

A solvent-controlled and heteroatom-dictated protocol for the transition metal-free addition of alkenyl Grignard reagents to lactam esters has been developed, leading to the chemo- and regioselective synthesis of lactam-tethered homoallylic ketones.

Download Full-text

ChemInform Abstract: Improvements and Applications of the Transition Metal-Free Asymmetric Allylic Alkylation Using Grignard Reagents and Magnesium Alanates.

10.1002/chin.201610049 ◽

2016 ◽

Vol 47 (10) ◽

pp. no-no

Author(s):

David Grassi ◽

Alexandre Alexakis

Keyword(s):

Transition Metal ◽

Grignard Reagents ◽

Allylic Alkylation ◽

Asymmetric Allylic Alkylation ◽

Download Full-text

Transition Metal-Free TEMPO-Catalyzed Oxidative Cross- Coupling of Nitrones with Alkynyl-Grignard Reagents

Advanced Synthesis & Catalysis ◽

10.1002/adsc.201100327 ◽

2011 ◽

Vol 353 (14-15) ◽

pp. 2708-2714 ◽

Author(s):

Sandip Murarka ◽

Armido Studer

Keyword(s):

Transition Metal ◽

Cross Coupling ◽

Grignard Reagents ◽

Download Full-text

Regioselective 1,4-conjugate aza-Michael addition of dienones with benzotriazole

Heterocyclic Communications ◽

10.1515/hc-2016-0182 ◽

2017 ◽

Vol 23 (4) ◽

Author(s):

Zheng Li ◽

Tianpeng Li ◽

Rugang Fu ◽

Jingya Yang

Keyword(s):

Transition Metal ◽

Michael Addition ◽

Potassium Acetate ◽

Mild Conditions

AbstractThe regioselective 1,4-conjugate aza-Michael addition of dienones with benzotriazole catalyzed by potassium acetate is described. A series of 3-(benzotriazol-1-yl)-1,5-diarylpent-4-en-1-ones were efficiently synthesized under mild conditions. This protocol has advantages of transition-metal free catalyst, high yield and high regioselectivity.

Download Full-text

Transition-Metal-Free Electrophilic Amination between Aryl Grignard Reagents andN-Chloroamines

Organic Letters ◽

10.1021/ol100235b ◽

2010 ◽

Vol 12 (7) ◽

pp. 1516-1519 ◽

Author(s):

Takuji Hatakeyama ◽

Yuya Yoshimoto ◽

Sujit K. Ghorai ◽

Masaharu Nakamura

Keyword(s):

Transition Metal ◽

Grignard Reagents ◽

Electrophilic Amination ◽

Download Full-text

Transition-Metal-Free Direct Arylation with Grignard Reagents

Synfacts ◽

10.1055/s-0033-1339407 ◽

2013 ◽

Vol 9 (08) ◽

pp. 0879-0879

Keyword(s):

Transition Metal ◽

Grignard Reagents ◽

Direct Arylation ◽

Download Full-text

Transition metal-free domino aryl-aryl coupling/phospha-Michael addition of diarylphosphinite to α,β-unsaturated ketones triggered by alkaline hydrolysis of (4-(2-alkenoyl)phenyl)triarylphosphonium salts

Phosphorus Sulfur and Silicon and the Related Elements ◽

10.1080/10426507.2021.1995385 ◽

2021 ◽

pp. 1-13

Author(s):

Wenhua Huang ◽

Jing-Yu Xue

Keyword(s):

Transition Metal ◽

Michael Addition ◽

Alkaline Hydrolysis ◽

Unsaturated Ketones ◽

Download Full-text

Transition-metal-free PhI(OAc)2-mediated oxidative S S and C N bond formation: Regioselective synthesis of 3H-1,2,4-dithiazol-3-imines

Tetrahedron Letters ◽

10.1016/j.tetlet.2019.151424 ◽

2020 ◽

Vol 61 (5) ◽

pp. 151424

Author(s):

Tumula Nagaraju ◽

Palakodety Radha Krishna

Keyword(s):

Transition Metal ◽

Bond Formation ◽

Regioselective Synthesis ◽

Download Full-text

Transition-Metal-Free Synthesis of Fluorinated Arenes from Perfluorinated Arenes Coupled with Grignard Reagents

Organometallics ◽

10.1021/om4011609 ◽

2014 ◽

Vol 33 (4) ◽

pp. 1079-1081 ◽

Author(s):

Yunqiang Sun ◽

Hongjian Sun ◽

Jiong Jia ◽

Aiqin Du ◽

Xiaoyan Li

Keyword(s):

Transition Metal ◽

Grignard Reagents ◽

Download Full-text

Metal-Free Michael-Addition-Initiated Three-Component Reaction for the Regioselective Synthesis of Highly Functionalized Pyridines: Scope, Mechanistic Investigations and Applications

European Journal of Organic Chemistry ◽

10.1002/ejoc.201300246 ◽

2013 ◽

Vol 2013 (19) ◽

pp. 4131-4145 ◽

Author(s):

Christophe Allais ◽

Frédéric Liéby-Muller ◽

Jean Rodriguez ◽

Thierry Constantieux

Keyword(s):

Michael Addition ◽

Regioselective Synthesis ◽

Three Component Reaction ◽

Mechanistic Investigations

Download Full-text

ChemInform Abstract: Regioselective Synthesis of Phenoxathiin Derivatives under Transition-Metal-Free Conditions.

10.1002/chin.201330183 ◽

2013 ◽

Vol 44 (30) ◽

pp. no-no

Author(s):

Fangdong Hu ◽

Xin Zhao ◽

Yanqiu Li ◽

Lei Feng ◽

Chen Ma

Keyword(s):

Transition Metal ◽

Regioselective Synthesis ◽

Download Full-text