ChemInform Abstract: Tandem Nucleophilic Addition/Oxa-Michael Reaction for the Synthesis of cis-2,6-Disubstituted Tetrahydropyrans.

ChemInform ◽  
2015 ◽  
Vol 46 (6) ◽  
pp. no-no
Author(s):  
Santosh J. Gharpure ◽  
J. V. K. Prasad ◽  
Kalisankar Bera
Keyword(s):  
Nucleophilic Addition ◽  
Michael Reaction

Tandem Nucleophilic Addition−Intramolecular Aza-Michael Reaction: Facile Synthesis of Chiral Fluorinated Isoindolines

2010 ◽  
Vol 12 (23) ◽  
pp. 5494-5497 ◽  
Author(s):  
Santos Fustero ◽  
Javier Moscardó ◽  
María Sánchez-Roselló ◽  
Elsa Rodríguez ◽  
Pablo Barrio
Keyword(s):  
Nucleophilic Addition ◽  
Michael Reaction ◽  
Facile Synthesis

Mechanism of Mukaiyama−Michael Reaction of Ketene Silyl Acetal:  Electron Transfer or Nucleophilic Addition?

1996 ◽  
Vol 61 (9) ◽  
pp. 2951-2962 ◽  
Author(s):  
Junzo Otera ◽  
Yukihiro Fujita ◽  
Nobuyuki Sakuta ◽  
Morifumi Fujita ◽  
Shunichi Fukuzumi
Keyword(s):  
Electron Transfer ◽  
Nucleophilic Addition ◽  
Michael Reaction

Synthesis of α-Thiooximes by Addition of Thiols to N,N-Bis(oxy)-enamines: A Comparative Study of S-, N-, and O-Nucleo­philes in Michael Reaction with Nitrosoalkene Species

Synlett ◽  
2018 ◽  
Vol 29 (10) ◽  
pp. 1334-1339 ◽  
Author(s):  
Alexey Sukhorukov ◽  
Yana Naumovich ◽  
Aleksandr Kokuev ◽  
Sema Ioffe
Keyword(s):  
Comparative Study ◽  
Nucleophilic Addition ◽  
Michael Reaction ◽  
Lewis Base ◽  
Base Catalysis ◽  
Relative Reactivity ◽  
Efficient Manner ◽  
Highly Efficient ◽  
Relative Nucleophilicity ◽  
First Time

Nucleophilic addition of thiols to N,N-bis(oxy)enamines (nitrosoalkene acetals) produce valuable α-thiooximes in a highly efficient manner. The reaction was found to be solvent-dependent, likely because of distinct mechanisms operating in nonpolar and basic solvents (involving either Brønsted acid or Lewis base catalysis). By performing a series of competition experiments, the relative reactivity of S-, N-, and O-nucleophiles in reaction with N,N-bis(oxy)enamines was determined for the first time. Interestingly, the relative nucleophilicity was found to be highly dependent on the solvent, which allows regioselective control of these reactions by using an appropriate medium.

ChemInform Abstract: Tandem Nucleophilic Addition-Intramolecular Aza-Michael Reaction: Facile Synthesis of Chiral Fluorinated Isoindolines.

ChemInform ◽  
2011 ◽  
Vol 42 (12) ◽  
pp. no-no
Author(s):  
Santos Fustero ◽  
Javier Moscardo ◽  
Maria Sanchez-Rosello ◽  
Elsa Rodriguez ◽  
Pablo Barrio
Keyword(s):  
Nucleophilic Addition ◽  
Michael Reaction ◽  
Facile Synthesis

Tandem Nucleophilic Addition/Oxa-Michael Reaction for the Synthesis ofcis-2,6-Disubstituted Tetrahydropyrans

2014 ◽  
Vol 2014 (17) ◽  
pp. 3570-3574 ◽  
Author(s):  
Santosh J. Gharpure ◽  
J. V. K. Prasad ◽  
Kalisankar Bera
Keyword(s):  
Nucleophilic Addition ◽  
Michael Reaction
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