ChemInform Abstract: Deep Eutectic Solvent Based on Choline Chloride and Malonic Acid as an Efficient and Reusable Catalytic System for One-Pot Synthesis of Functionalized Pyrroles.
Deep eutectic solvent (DES) based on choline chloride and malonic acid was applied as catalyst and reaction medium for synthesis of pyrroles by one-pot, four-component reaction of amines, aldehydes, 1,3-dicarbonyl compounds and nitromethane.
AbstractAn efficient one-pot synthesis of polyhydroacridines and polyhydroquinolines through the Hantzsch reaction in deep eutectic solvent choline chloride/urea (1:2) has been developed. Good to excellent yields, broad substrate compatibility as well as the reusability of the solvent are the major advantages of the present protocol.
An efficient and green protocol for the one-pot synthesis of 3-amido-alkyl-4-hydroxycoumarin derivatives by choline chloride/urea as a deep eutectic solvent