ChemInform Abstract: Construction of Chiral α-Amino Quaternary Stereogenic Centers via Phase-Transfer Catalyzed Enantioselective α-Alkylation of α-Amidomalonates.

ChemInform ◽  
2015 ◽  
Vol 46 (32) ◽  
pp. no-no
Author(s):  
Hyeung-geun Park ◽  
et al.
Keyword(s):  
Phase Transfer ◽  
Stereogenic Centers ◽  
Quaternary Stereogenic Centers

Phase-transfer catalyzed enantioselective α-alkylation of α-acyloxymalonates: construction of chiral α-hydroxy quaternary stereogenic centers

RSC Advances ◽  
2016 ◽  
Vol 6 (81) ◽  
pp. 77427-77430 ◽  
Author(s):  
Min Woo Ha ◽  
Sujee Choi ◽  
Seek Kim ◽  
Jun Young Lee ◽  
Jae Kyun Lee ◽  
...  
Keyword(s):  
Natural Products ◽  
Efficient Method ◽  
Phase Transfer ◽  
Enantioselective Synthesis ◽  
Tertiary Alcohols ◽  
Stereogenic Centers ◽  
Quaternary Stereogenic Centers

The enantioselective synthesis of α-acyloxy-α-alkylmalonates was developed as an efficient method for producing chiral α-tertiary alcohols, which are potentially valuable intermediates in the synthesis of natural products and pharmaceuticals.

Enantioselective Synthesis of Chiral α-Thio-Quaternary Stereogenic Centers via Phase-Transfer-Catalyzed α-Alkylation of α-Acylthiomalonates

2018 ◽  
Vol 83 (2) ◽  
pp. 1011-1018 ◽  
Author(s):  
Min Woo Ha ◽  
Jun Young Lee ◽  
Doyoung Kim ◽  
Geumwoo Lee ◽  
Jae Kyun Lee ◽  
...  
Keyword(s):  
Phase Transfer ◽  
Enantioselective Synthesis ◽  
Stereogenic Centers ◽  
Quaternary Stereogenic Centers

Construction of Chiral α-Amino Quaternary Stereogenic Centers via Phase-Transfer Catalyzed Enantioselective α-Alkylation of α-Amidomalonates

2015 ◽  
Vol 80 (6) ◽  
pp. 3270-3279 ◽  
Author(s):  
Min Woo Ha ◽  
Myungmo Lee ◽  
Sujee Choi ◽  
Seek Kim ◽  
Suckchang Hong ◽  
...  
Keyword(s):  
Phase Transfer ◽  
Stereogenic Centers ◽  
Quaternary Stereogenic Centers

ChemInform Abstract: Phase-Transfer Catalyzed Enantioselective α-Alkylation of α-Acyloxymalonates: Construction of Chiral α-Hydroxy Quaternary Stereogenic Centers.

ChemInform ◽  
2016 ◽  
Vol 47 (52) ◽  
Author(s):  
Min Woo Ha ◽  
Sujee Choi ◽  
Seek Kim ◽  
Jun Young Lee ◽  
Jae Kyun Lee ◽  
...  
Keyword(s):  
Phase Transfer ◽  
Stereogenic Centers ◽  
Quaternary Stereogenic Centers

All-Carbon Quaternary Stereogenic Centers in Acyclic Systems through the Creation of Several C–C Bonds per Chemical Step

2014 ◽  
Vol 136 (7) ◽  
pp. 2682-2694 ◽  
Author(s):  
Ilan Marek ◽  
Yury Minko ◽  
Morgane Pasco ◽  
Tom Mejuch ◽  
Noga Gilboa ◽  
...  
Keyword(s):  
Stereogenic Centers ◽  
The Creation ◽  
Quaternary Stereogenic Centers

Chirality Transfer from a Chiral Primary Alcohol Equivalent Through Allyl Cyanate-to-Isocyanate Rearrangement: Synthesis of (+)-Geranyllinaloisocyanide

Synthesis ◽  
2019 ◽  
Vol 51 (15) ◽  
pp. 2959-2964 ◽  
Author(s):  
Yoshiyasu Ichikawa ◽  
Hirofumi Morimoto ◽  
Toshiya Masuda
Keyword(s):  
Natural Product ◽  
Primary Alcohol ◽  
Marine Natural Product ◽  
Chirality Transfer ◽  
New Approach ◽  
Stereogenic Centers ◽  
Quaternary Stereogenic Centers

A new approach was developed to construct quaternary stereogenic centers bearing nitrogen substituents in an enantioselective manner. The strategy takes advantage of [1,3]-chirality transfer from a chiral primary alcohol equivalent through an allyl cyanate-to-isocyanate rearrangement. This approach was employed in an efficient eight-step synthesis of the marine natural product, (+)-geranyllinaloisocyanide, in 43% overall yield.

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