Celecoxib containing pyrazole derivatives were synthesized by path aldol condensation of
substituted ketone with trifluoroethyl acetate subsequently by cyclization of the formed chalcones with
4-methanesulfonylphenylhydrazine. Here, a one-pot synthesis of celecoxib and substituted analogues
have been reported which are nonsteroidal anti-inflammatory drugs for their cyclooxygenase (COX)
inhibition, anti-inflammatory activity and ulcerogenic liability. In order to intermediate work-up, a continuous
one-pot synthesis has been developed, performing the entire reaction sequence that results in a
shorter time with good yield.
