scholarly journals Response to Giovanni Battista Morgagni and the Foundation of Modem Medicine

2016 ◽  
Vol 39 (8) ◽  
pp. 484-485 ◽  
Author(s):  
Flávia F. A. Vale ◽  
Paulo C. R. P. Corrêa



2018 ◽  
Vol 42 (4) ◽  
pp. 47-52
Author(s):  
Y. Y. Rakina ◽  
M. V. Zav’yalova ◽  
N. V. Krakhmal ◽  
A. P. Koshel ◽  
S. G. Afanasyev ◽  
...  

In recent years, especially in developed countries, there has been an increase in the incidence of pancreatic cancer. Only 20% of tumors at the time of diagnosis are evaluated as resectable, but in these cases, the prognosis of the disease is unfavorable. The overall 5-year survival rate does not exceed 5%. Pancreatic cancer was described in the 1760s by Giovanni Battista Morgagni in his classic book “De Sedibus et Causis Morborum per Anatomen Indigatis”. Over the next 200 years, pathologists significantly improved our understanding of the macro- and microscopic features of this disease. At the same time, morphological research remained the basis of diagnostics for centuries. The introduction of immunohistochemical studies into clinical practice in the late 1970s and early 1980s radically changed our approach to diagnosing this disease. Evaluation of morphological features, as well as features of expression of markers that determine the invasive potential of such neoplasms, can serve in the future as a fundamental basis in solving questions concerning possible factors of prognosis upon malignant tumors of such a localization. Aim of research — to study the morphological and immunohistochemical features of ductal pancreatic adenocarcinoma. Materials and methods. The study included 84 patients with pancreatic cancer T1-4N0-2M0-1 stage, aged from 37 to 83, who underwent surgical treatment. Morphological study of the operating material was carried out. The condition for inclusion in the study was a histotype of the tumor, namely ductal pancreatic adenocarcinoma. Posting of the material, preparation of histological preparations, coloring, immunohistochemical examination were carried out according to a standard procedure. Results and conclusion. The study made it possible to characterize the tumor morphology, as well as the features of expression of markers associated with more evident invasive characteristics of the tumor. The results of this work may be of interest in terms of their further comparison with the parameters of various forms of progression upon pancreatic cancer.



2008 ◽  
Vol 43 (4) ◽  
pp. 729-733 ◽  
Author(s):  
Augusto Zani ◽  
Denis A. Cozzi


Reumatismo ◽  
2011 ◽  
Vol 57 (4) ◽  
Author(s):  
P. Lazzarin ◽  
G. Pasero ◽  
P. Marson ◽  
A. Cecchetto ◽  
G. Zanchin


2015 ◽  
Vol 263 (5) ◽  
pp. 1050-1052 ◽  
Author(s):  
Çağatay Öncel ◽  
Sevin Baser


2015 ◽  
Vol 18 (6) ◽  
pp. 458-465 ◽  
Author(s):  
Carlos R. Abramowsky ◽  
Frank E. Berkowitz


2000 ◽  
Vol 23 (10) ◽  
pp. 792-794 ◽  
Author(s):  
Hector O. Ventura


2016 ◽  
Vol 12 (1) ◽  
pp. 123-123 ◽  
Author(s):  
Emanuela Gualdi-Russo ◽  
Luciana Zaccagni ◽  
Valentina Russo


2019 ◽  
Vol 2 (1) ◽  
pp. 11-12
Author(s):  
IULIAN SLAVU ◽  
Alecu Lucian ◽  
Tulin Adrian

Anterior diaphragmatic hernias are very rare surgical entities, scarce in symptoms, which occur through openings of the costal and sternal fascicules of the diaphragm. First described by Giovanni Battista Morgagni, in 1769, they are known under many names:  Morgagni, Morgagni-Larrey. These hernias can develop in the left hemidiaphragm, right hemidiaphragm or bilateral. The preferred treatment when available is the laparoscopic suture of the defect.                We present the case of a 52 years old female patient, with morbid obesity (BMI = 44.10 kg/m²) and Morgagni hernia. Other associated pathologies of the patient were high blood pressure, autoimmune thyroiditis, and sleep apneea. The initial diagnosis of diaphragmatic hernia was made a year earlier at a CT investigation. Laparoscopic sleeve gastrectomy and suture of the diaphragmatic defect were achieved without incidents during one single surgical intervention. A drainage tube was placed in the remaining cavity of the hernia. The hernia sac was conserved and used to reinforce the defect.  The concurrent suture of the diaphragmatic hernia and sleeve gastrectomy do not increase the postoperative morbidity. The recovery was uneventful, thus the patient was spared a second surgical intervention . If present, these hernias are quickly identified due to the fact that laparoscopy allows a through exploration of the diaphragm. When diagnosed these defects should be repaired by suture due to the fact that they can cause life threating complications to the patient such as intestinal obstruction or gastro-intestinal bleeding if elements of the digestive tract are incarcerated in the defect.



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