scholarly journals Somatotopic organization of central arbors from nociceptive afferents develops independently of their intact peripheral target innervation

2018 ◽  
Vol 526 (18) ◽  
pp. 3058-3065 ◽  
Author(s):  
William Olson ◽  
Wenqin Luo
Keyword(s):  
Peripheral Target ◽  
Somatotopic Organization ◽  
Target Innervation ◽  
Nociceptive Afferents

scholarly journals Region Specific Central Arbor Morphologies of Nociceptive Afferents Develop Independently of Their Peripheral Target Innervation

2018 ◽  
Author(s):  
William Olson ◽  
Wenqin Luo
Keyword(s):  
Transmission Efficiency ◽  
Spinal Cord Dorsal Horn ◽  
Peripheral Target ◽  
Early Postnatal Development ◽  
Sensory Pathways ◽  
Target Innervation ◽  
Cell Ablation ◽  
Spinal Cord Dorsal ◽  
Nociceptive Afferents ◽  
Central Terminal

ABSTRACTFunctionally important regions of sensory maps are overrepresented in the sensory pathways and cortex, but the underlying developmental mechanisms are not clear. In the spinal cord dorsal horn (DH), we recently showed that paw innervating Mrgprd+ non-peptidergic nociceptors display distinctive central arbor morphologies that well correlate with increased synapse transmission efficiency and heightened sensitivity of distal limb skin. Given that peripheral and central arbor formation of Mrgprd+ neurons co-occurs around the time of birth, we tested whether peripheral cues from different skin areas and/or postnatal reorganization mechanisms could instruct this somatotopic difference among central arbors. We found that, while terminal outgrowth/refinement occurs during early postnatal development in both the skin and the DH, postnatal refinement of central terminals precedes that of peripheral terminals. Further, we used single-cell ablation of Ret to genetically disrupt epidermal innervation of Mrgprd+ neurons and revealed that the somatotopic difference among their central arbors was unaffected by this manipulation. Finally, we saw that region-specific Mrgprd+ central terminal arbors are present from the earliest postnatal stages, before skin terminals are evident. Together, our data indicate that region-specific organization of Mrgprd+ neuron central arbors develops independently of peripheral target innervation and is present shortly after initial central terminal formation, suggesting that either cell-intrinsic and/or DH local signaling may establish this somatotopic difference.

scholarly journals Uncoupling of Molecular Maturation from Peripheral Target Innervation in Nociceptors Expressing a Chimeric TrkA/TrkC Receptor

PLoS Genetics ◽  
2014 ◽  
Vol 10 (2) ◽  
pp. e1004081 ◽  
Author(s):  
Svetlana Gorokhova ◽  
Stéphane Gaillard ◽  
Louise Urien ◽  
Pascale Malapert ◽  
Wassim Legha ◽  
...  
Keyword(s):  
Peripheral Target ◽  
Target Innervation

scholarly journals Specific Subtypes of Cutaneous Mechanoreceptors Require Neurotrophin-3 Following Peripheral Target Innervation

Neuron ◽  
1996 ◽  
Vol 16 (2) ◽  
pp. 287-295 ◽  
Author(s):  
Matti S Airaksinen ◽  
Martin Koltzenburg ◽  
Gary R Lewin ◽  
Yasuo Masu ◽  
Christian Helbig ◽  
...  
Keyword(s):  
Peripheral Target ◽  
Cutaneous Mechanoreceptors ◽  
Target Innervation ◽  
Neurotrophin 3

scholarly journals Involvement of IKAP in Peripheral Target Innervation and in Specific JNK and NGF Signaling in Developing PNS Neurons

PLoS ONE ◽  
2014 ◽  
Vol 9 (11) ◽  
pp. e113428 ◽  
Author(s):  
Anastasia Abashidze ◽  
Veronica Gold ◽  
Yaron Anavi ◽  
Hayit Greenspan ◽  
Miguel Weil
Keyword(s):  
Peripheral Target ◽  
Target Innervation ◽  
Ngf Signaling

154 Specific subtypes of cutaneous mechanoreceptors require neurotrophin-3 following peripheral target innervation

1996 ◽  
Vol 14 ◽  
pp. 87-87 ◽  
Author(s):  
M.S. Airaksinen ◽  
M. Koltzenburg ◽  
G.R. Lewin ◽  
Y. Masu ◽  
C. Helbig ◽  
...  
Keyword(s):  
Peripheral Target ◽  
Cutaneous Mechanoreceptors ◽  
Target Innervation ◽  
Neurotrophin 3

On Why Objects Appear Smaller in the Visual Periphery

2019 ◽  
Vol 31 (1) ◽  
pp. 88-96 ◽  
Author(s):  
Wladimir Kirsch ◽  
Roland Pfister ◽  
Wilfried Kunde
Keyword(s):  
Visual Field ◽  
Visual System ◽  
Structural Properties ◽  
Spatial Attention ◽  
Visuospatial Attention ◽  
Peripheral Target ◽  
Perceptual Distortion ◽  
Visual Periphery ◽  
Peripheral Location ◽  
Exogenous Cue

An object appears smaller in the periphery than in the center of the visual field. In two experiments ( N = 24), we demonstrated that visuospatial attention contributes substantially to this perceptual distortion. Participants judged the size of central and peripheral target objects after a transient, exogenous cue directed their attention to either the central or the peripheral location. Peripheral target objects were judged to be smaller following a central cue, whereas this effect disappeared completely when the peripheral target was cued. This outcome suggests that objects appear smaller in the visual periphery not only because of the structural properties of the visual system but also because of a lack of spatial attention.

Target innervation is necessary for neuronal polyploidization in the terrestrial slugLimax

2013 ◽  
Vol 73 (8) ◽  
pp. 609-620 ◽  
Author(s):  
Ryota Matsuo ◽  
Miki Yamagishi ◽  
Kyoko Wakiya ◽  
Yoko Tanaka ◽  
Etsuro Ito
Keyword(s):  
Target Innervation
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