scholarly journals Relationship of the Calcitonin Gene‐Related Peptide Monoclonal Antibody Galcanezumab Pharmacokinetics and Capsaicin‐Induced Dermal Blood Flow in Healthy Subjects

2021 ◽  
Author(s):  
Jill Fiedler‐Kelly ◽  
Eyas Raddad ◽  
Jan Hoon ◽  
Elizabeth A. Ludwig ◽  
Julie Passarell ◽  
...  
Keyword(s):  
Monoclonal Antibody ◽  
Blood Flow ◽  
Healthy Subjects ◽  
Calcitonin Gene Related Peptide ◽  
Related Peptide ◽  
Calcitonin Gene ◽  
Relationship Of ◽  
Dermal Blood Flow

Translational Pharmacodynamics of Calcitonin Gene-Related Peptide Monoclonal Antibody LY2951742 in a Capsaicin-Induced Dermal Blood Flow Model

2015 ◽  
Vol 354 (3) ◽  
pp. 350-357 ◽  
Author(s):  
Steve Vermeersch ◽  
Robert J. Benschop ◽  
Anne Van Hecken ◽  
David Monteith ◽  
Victor J. Wroblewski ◽  
...  
Keyword(s):  
Monoclonal Antibody ◽  
Blood Flow ◽  
Flow Model ◽  
Calcitonin Gene Related Peptide ◽  
Related Peptide ◽  
Calcitonin Gene ◽  
Dermal Blood Flow ◽  
Blood Flow Model

Galcanezumab for the prevention of migraine

2020 ◽  
Author(s):  
Lindsay M Frerichs ◽  
Deborah I Friedman
Keyword(s):  
Monoclonal Antibody ◽  
Clinical Efficacy ◽  
Preventive Treatment ◽  
Calcitonin Gene Related Peptide ◽  
Efficacy And Safety ◽  
Related Peptide ◽  
Calcitonin Gene

Migraine is a common and disabling disorder affecting approximately 1.02 billion people worldwide. Calcitonin gene-related peptide (CGRP) has been identified as playing an important role in the pathophysiology of migraine and several migraine-specific therapies targeting the CGRP ligand or its receptor have been approved since 2018 for the acute and preventive treatment of migraine. This review focuses on the pharmacology, clinical efficacy and safety/tolerability of galcanezumab, an anti-CGRP monoclonal antibody approved for the prevention of migraine.

Effect of neurogenic irritation and calcitonin gene-related peptide (CGRP) on ocular blood flow in the rabbit

1988 ◽  
Vol 7 (7) ◽  
pp. 695-703 ◽  
Author(s):  
Kari Krootila ◽  
Hannu Uusitalo ◽  
Arto Palkama
Keyword(s):  
Blood Flow ◽  
Ocular Blood Flow ◽  
Calcitonin Gene Related Peptide ◽  
Related Peptide ◽  
Calcitonin Gene

scholarly journals Mechanisms of calcitonin gene-related peptide-induced increases of pulmonary blood flow in fetal sheep

2000 ◽  
Vol 279 (4) ◽  
pp. H1654-H1660 ◽  
Author(s):  
Yasushi Takahashi ◽  
Maartje De Vroomen ◽  
Christine Roman ◽  
Michael A. Heymann
Keyword(s):  
Nitric Oxide ◽  
Blood Flow ◽  
Pulmonary Blood Flow ◽  
Pulmonary Arteries ◽  
Calcitonin Gene Related Peptide ◽  
Fetal Sheep ◽  
Nitric Oxide Synthase Inhibitor ◽  
Flow Transducer ◽  
Related Peptide ◽  
Calcitonin Gene

Fetal pulmonary blood flow is regulated by various vasoactive substances. One, calcitonin gene-related peptide (CGRP), increases pulmonary blood flow. We examined four key physiological mechanisms underlying this response using the blocker drugs CGRP receptor blocker (CGRP8–37), nitric oxide synthase inhibitor [ N ω-nitro-l-arginine (l-NNA)], adenosine triphosphate-dependent potassium (KATP) channel blocker (glibenclamide), and cyclooxygenase inhibitor (indomethacin) in 17 near-term fetal sheep. Catheters were placed in the left (LPA) and main pulmonary arteries, and an ultrasonic flow transducer was placed around the LPA to measure flow continuously. CGRP was injected directly into the LPA (mean 1.02 μg/kg) before and after blockade, and responses to CGRP were statistically compared. Before blockade, CGRP increased LPA blood flow from 23 ± 25 to 145 ± 77 ml/min (means ± SD), and these increases were significantly attenuated by CGRP8–37( n = 6; 91% inhibition), l-NNA ( n = 6; 86% inhibition), and glibenclamide ( n = 6; 69% inhibition). No significant changes were found with indomethacin ( n = 6; 4% inhibition). Thus, in the fetal pulmonary circulation, CGRP increases pulmonary blood flow not only through its specific receptor but also, in part, through nitric oxide release and KATP channel activation.

The efficacy and safety of calcitonin gene-related peptide monoclonal antibody for episodic migraine: a meta-analysis

2018 ◽  
Vol 39 (12) ◽  
pp. 2097-2106 ◽  
Author(s):  
Yuhan Zhu ◽  
Yanyan Liu ◽  
Jing Zhao ◽  
Qingqing Han ◽  
Lei Liu ◽  
...  
Keyword(s):  
Monoclonal Antibody ◽  
Meta Analysis ◽  
Episodic Migraine ◽  
Calcitonin Gene Related Peptide ◽  
Efficacy And Safety ◽  
Related Peptide ◽  
Calcitonin Gene

Effects of calcitonin gene-related peptide on tissue survival, blood flow and neutrophil recruitment in experimental skin flaps

1999 ◽  
Vol 52 (4) ◽  
pp. 299-303 ◽  
Author(s):  
G.Brodda Jansen ◽  
L. Törkvist ◽  
O. Löfgren ◽  
J. Raud ◽  
T. Lundeberg
Keyword(s):  
Blood Flow ◽  
Calcitonin Gene Related Peptide ◽  
Neutrophil Recruitment ◽  
Skin Flaps ◽  
Related Peptide ◽  
Calcitonin Gene

scholarly journals High‐dose phenylephrine increases meningeal blood flow through TRPV1 receptor activation and release of calcitonin gene‐related peptide

2019 ◽  
Vol 24 (2) ◽  
pp. 383-397 ◽  
Author(s):  
Mária Dux ◽  
Alexandru Babes ◽  
Jessica Manchen ◽  
Julika Sertel‐Nakajima ◽  
Birgit Vogler ◽  
...  
Keyword(s):  
Blood Flow ◽  
Receptor Activation ◽  
Calcitonin Gene Related Peptide ◽  
High Dose ◽  
Trpv1 Receptor ◽  
Related Peptide ◽  
Calcitonin Gene ◽  
Meningeal Blood Flow ◽  
Flow Through

The effects of calcitonin gene-related peptide (CGRP) on cochlear and mucosal blood flow in the albino rabbit

1991 ◽  
Vol 52 (2) ◽  
pp. 321-328 ◽  
Author(s):  
Maria Hillerdal ◽  
Sven E Andersson
Keyword(s):  
Blood Flow ◽  
Mucosal Blood Flow ◽  
Calcitonin Gene Related Peptide ◽  
Albino Rabbit ◽  
Related Peptide ◽  
Calcitonin Gene

The influence of neurokinins and calcitonin gene-related peptide on cerebral blood flow in anaesthetized guinea-pigs

Neuropeptides ◽  
1993 ◽  
Vol 24 (6) ◽  
pp. 343-349 ◽  
Author(s):  
D.T. Beattie ◽  
D.K. Mcneil ◽  
H.E. Connor
Keyword(s):  
Blood Flow ◽  
Cerebral Blood Flow ◽  
Guinea Pigs ◽  
Calcitonin Gene Related Peptide ◽  
Related Peptide ◽  
Calcitonin Gene
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