scholarly journals Treatment intensification in patients with inadequate glycemic control on basal insulin: rationale and clinical evidence for the use of short‐acting and other glucagon‐like peptide‐1 receptor agonists

2016 ◽  
Vol 32 (6) ◽  
pp. 497-511 ◽  
Author(s):  
Francesco Giorgino ◽  
Riccardo C. Bonadonna ◽  
Sandro Gentile ◽  
Roberto Vettor ◽  
Paolo Pozzilli
Keyword(s):  
Glycemic Control ◽  
Basal Insulin ◽  
Clinical Evidence ◽  
Treatment Intensification ◽  
Short Acting ◽  
Receptor Agonists ◽  
Glucagon Like Peptide ◽  
Glucagon Like Peptide 1 ◽  
Inadequate Glycemic Control

scholarly journals Initiating Titratable Fixed-Ratio Combinations of Basal Insulin Analogs and Glucagon-Like Peptide-1 Receptor Agonists: What You Need to Know

2018 ◽  
Vol 36 (2) ◽  
pp. 174-182 ◽  
Author(s):  
Neil Skolnik ◽  
Debbie Hinnen ◽  
Yan Kiriakov ◽  
Melissa L. Magwire ◽  
John R. White
Keyword(s):  
Basal Insulin ◽  
Fixed Ratio ◽  
Insulin Analogs ◽  
Receptor Agonists ◽  
Glucagon Like Peptide ◽  
Glucagon Like Peptide 1

scholarly journals Lixisenatide – A New Glucagon-like Peptide 1 Receptor Agonist in the Treatment of Type 2 Diabetes

2010 ◽  
Vol 9 (2) ◽  
pp. 76 ◽  
Author(s):  
Josep Vidal ◽  
Keyword(s):  
Type 2 Diabetes ◽  
Glycaemic Control ◽  
Basal Insulin ◽  
Glycated Haemoglobin ◽  
Insulin Analogues ◽  
Receptor Agonists ◽  
Glucagon Like Peptide ◽  
Glucagon Like Peptide 1 ◽  
Long Acting

Optimal glycaemic control is essential to managing risks in patients with type 2 diabetes. However, glycaemic control remains poor among type 2 diabetes patients, particularly the control of post-prandial glucose (PPG). Almost half of patients treated with basal insulin and oral anti-diabetic drugs (OADs) do not achieve their glycated haemoglobin (HbA1c) goals, despite achieving fasting plasma glucose (FPG) control. Glycaemic control targets have emphasised FPG targets, but PPG contributes significantly to overall glycaemic control in type 2 diabetes. Glucagon-like peptide 1 (GLP-1) receptor agonists have shown substantial efficacy in improving overall glycaemic control but have differing effects on PPG, which is a result of their different mechanisms of action. Lixisenatide is unique among existing GLP-1 receptor agonists in that it is short acting but given as a once daily dose, and exerts its main effects during the prandial period. It has demonstrated efficacy in an extensive clinical trial programme. In particular, it has shown a beneficial effect on PPG compared with existing GLP-1 receptor agonists, probably a result of its effect on slowing gastric emptying. This has provided a strong rationale for its use as add-on therapy to long-acting basal insulin analogues, in cases where the latter is not providing adequate glycaemic control. The additive effects on glycaemic control may lead to a new treatment approach to manage blood glucose and prevent long-term complications in patients with type 2 diabetes.

Beyond glycemic control: nephroprotective effects of glucagon-like peptide 1 receptor agonists

Nephrology ◽  
2021 ◽  
Vol 3_2021 ◽  
pp. 84-91
Author(s):  
M.S. Shamkhalova Shamkhalova ◽  
I.A. Sklyanik Sklyanik ◽  
M.V. Shestakova Shestakova ◽  
Keyword(s):  
Glycemic Control ◽  
Receptor Agonists ◽  
Glucagon Like Peptide ◽  
Glucagon Like Peptide 1
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