Diastereoselective Cyclopropanation through Michael Addition-Initiated Ring Closure between α,α-Dibromoketones and α,β-Unsaturated Fischer Carbene Complexes

2020 ◽  
Vol 2020 (4) ◽  
pp. 429-436
Author(s):  
Tomáš Tobrman ◽  
Martin Krupička ◽  
Peter Polák ◽  
Hana Dvořáková ◽  
Marek Čubiňák ◽  
...  
Keyword(s):  
Michael Addition ◽  
Ring Closure ◽  
Fischer Carbene Complexes ◽  
Carbene Complexes ◽  
Fischer Carbene

Fischer carbene complexes. A new tool for heterocyclic synthesis

2002 ◽  
Vol 74 (8) ◽  
pp. 1317-1325 ◽  
Author(s):  
José Barluenga
Keyword(s):  
Michael Addition ◽  
Heterocyclic Compounds ◽  
Short Review ◽  
Enantioselective Synthesis ◽  
Heterocyclic Synthesis ◽  
Fischer Carbene Complexes ◽  
Carbene Complexes ◽  
Fischer Carbene ◽  
Stereogenic Centers ◽  
Sequential Processes

This short review covers our contribution in the field of the application of group 6 Fischer carbene complexes toward the synthesis of heterocyclic compounds. Alkenyl and alkynyl carbene complexes are suitable partners in [2+2], [3+2], [4+2], and [4+3] cycloaddition reactions. Moreover, chiral alkenyl carbene complexes react in sequential processes involving an initial Michael addition of a ketone lithium enolate to afford lactones with up to five consecutive stereogenic centers. Based on this strategy, we have devised a new method for the enantioselective synthesis of eight-membered carbocycles.

Sign in / Sign up

Export Citation Format

Share Document