scholarly journals Quantitative differentiation of whole smoke solution‐induced mutagenicity in the mouse lymphoma assay

2017 ◽  
Vol 59 (2) ◽  
pp. 103-113 ◽  
Author(s):  
Xiaoqing Guo ◽  
Robert H. Heflich ◽  
Stacey L. Dial ◽  
Mamata De ◽  
Patricia A. Richter ◽  
...  
Keyword(s):  
Mouse Lymphoma Assay ◽  
Whole Smoke ◽  
Mouse Lymphoma

scholarly journals In vitro genotoxicity evaluation and metabolic study of residual glutaraldehyde in animal-derived biomaterials

2020 ◽  
Vol 7 (6) ◽  
pp. 619-625
Author(s):  
Jianfeng Shi ◽  
Huan Lian ◽  
Yuanli Huang ◽  
Danmei Zhao ◽  
Han Wang ◽  
...  
Keyword(s):  
Metabolic Activation ◽  
Chemical Toxicity ◽  
Major Health ◽  
Mouse Lymphoma Assay ◽  
Metabolic Mechanism ◽  
Mutagenic Effects ◽  
Mouse Lymphoma ◽  
General Balance ◽  
In Vitro Genotoxicity

Abstract Glutaraldehyde (GA) is an important additive that is mainly used in animal-derived biomaterials to improve their mechanical and antimicrobial capacities. However, GA chemical toxicity and the metabolic mechanism remain relatively unknown. Therefore, residual GA has always been a major health risk consideration for animal-derived medical devices. In this study, extracts of three bio-patches were tested via the GA determination test and mouse lymphoma assay (MLA). The results showed that dissolved GA was a potential mutagen, which could induce significant cytotoxic and mutagenic effects in mouse lymphoma cells. These toxic reactions were relieved by the S9 metabolic activation (MA) system. Furthermore, we confirmed that GA concentration decreased and glutaric acid was generated during the catalytic process. We revealed GA could be oxidized via cytochrome P450 which was the main metabolic factor of S9. We found that even though GA was possibly responsible for positive reactions of animal-derived biomaterials’ biocompatibility evaluation, it may not represent the real situation occurring in human bodies, owing to the presence of various detoxification mechanisms including the S9 system. Overall, in order to achieve a general balance between risk management and practical application, rational decisions based on comprehensive analyses must be considered.

Methapyrilene is a genotoxic carcinogen: Studies on methapyrilene and pyrilamine in the L5178Y/TK+/− mouse lymphoma assay

1987 ◽  
Vol 189 (3) ◽  
pp. 285-297 ◽  
Author(s):  
N.T. Turner ◽  
J.L. Woolley ◽  
J.C. Hozier ◽  
J.R. Sawyer ◽  
D. Clive
Keyword(s):  
Genotoxic Carcinogen ◽  
Mouse Lymphoma Assay ◽  
Mouse Lymphoma

Induced hepatocytes as a metabolic activation system for the mouse-lymphoma assay

1989 ◽  
Vol 223 (3) ◽  
pp. 295-302 ◽  
Author(s):  
Linda A. Oglesby ◽  
Karen Harrington Brock ◽  
Martha M. Moore
Keyword(s):  
Metabolic Activation ◽  
Mouse Lymphoma Assay ◽  
Activation System ◽  
Mouse Lymphoma

scholarly journals Quantitative analysis of the relative mutagenicity of five chemical constituents of tobacco smoke in the mouse lymphoma assay

Mutagenesis ◽  
2015 ◽  
Vol 31 (3) ◽  
pp. 287-296 ◽  
Author(s):  
Xiaoqing Guo ◽  
Robert H. Heflich ◽  
Stacey L. Dial ◽  
Patricia A. Richter ◽  
Martha M. Moore ◽  
...  
Keyword(s):  
Quantitative Analysis ◽  
Tobacco Smoke ◽  
Chemical Constituents ◽  
Mouse Lymphoma Assay ◽  
Mouse Lymphoma

scholarly journals The mouse lymphoma assay in the wake of ICH4where are we now?

Mutagenesis ◽  
1999 ◽  
Vol 14 (3) ◽  
pp. 265-270 ◽  
Author(s):  
J. Cole
Keyword(s):  
Mouse Lymphoma Assay ◽  
Mouse Lymphoma

P XIX.12 The mouse lymphoma assay — universal catchall?

1997 ◽  
Vol 379 (1) ◽  
pp. S195
Author(s):  
Martha M. Moore ◽  
Jane Cole
Keyword(s):  
Mouse Lymphoma Assay ◽  
Mouse Lymphoma

Suitable top concentration for tests with mammalian cells: Mouse lymphoma assay workgroup

2011 ◽  
Vol 723 (2) ◽  
pp. 84-86 ◽  
Author(s):  
Martha M. Moore ◽  
Masamitsu Honma ◽  
Julie Clements ◽  
Takumi Awogi ◽  
George R. Douglas ◽  
...  
Keyword(s):  
Mammalian Cells ◽  
Mouse Lymphoma Assay ◽  
Mouse Lymphoma

Mouse Lymphoma Assay

2014 ◽  
pp. 397-398
Author(s):  
R.C. Guy
Keyword(s):  
Mouse Lymphoma Assay ◽  
Mouse Lymphoma
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