A Phase I Dose-Ranging Safety and Pharmacokinetics Study of a Novel Oral Thromboxane Synthase Inhibitor, FCE 22, 178

The Journal of Clinical Pharmacology ◽

10.1002/j.1552-4604.1993.tb04672.x ◽

1993 ◽

Vol 33 (4) ◽

pp. 373-380 ◽

Author(s):

Ronald C. Li ◽

Prem K. Narang ◽

Richard C. Lewis ◽

Naomi Z. Hatfield ◽

David T. Rossi ◽

...

Keyword(s):

Phase I ◽

Thromboxane Synthase ◽

Pharmacokinetics Study ◽

Thromboxane Synthase Inhibitor ◽

Dose Ranging ◽

Synthase Inhibitor

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Inhibition of Arachidonate-Induced Human Platelet Aggregation by a Single Low Oral Dose of Aspirin in Combination with a Thromboxane Synthase Inhibitor

Thrombosis and Haemostasis ◽

10.1055/s-0038-1661177 ◽

1984 ◽

Vol 52 (02) ◽

pp. 215-215 ◽

Author(s):

Chiara Cerletti ◽

Grazyna Rajtar ◽

Vittorio Bertelé ◽

Giovanni de Gaetano

Keyword(s):

Platelet Aggregation ◽

Oral Dose ◽

Human Platelet ◽

Thromboxane Synthase ◽

Human Platelet Aggregation ◽

Thromboxane Synthase Inhibitor ◽

Synthase Inhibitor

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A Convergent Synthesis of CGS23305, A Thromboxane Synthase Inhibitor

Synthesis ◽

10.1055/s-1999-3458 ◽

1999 ◽

Vol 1999 (05) ◽

pp. 769-774 ◽

Author(s):

Andrew T. Bach ◽

John A. Carlson ◽

Peter P. Giannousis

Keyword(s):

Thromboxane Synthase ◽

Convergent Synthesis ◽

Thromboxane Synthase Inhibitor ◽

Synthase Inhibitor

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In Vitro and in Vivo Pharmacological Characterization of BM-613 [N-n-Pentyl-N′-[2-(4′-methylphenylamino)-5-nitrobenzenesulfonyl]urea], a Novel Dual Thromboxane Synthase Inhibitor and Thromboxane Receptor Antagonist

Journal of Pharmacology and Experimental Therapeutics ◽

10.1124/jpet.104.079301 ◽

2004 ◽

Vol 313 (1) ◽

pp. 293-301 ◽

Author(s):

Julien Hanson ◽

Stephanie Rolin ◽

Denis Reynaud ◽

Na Qiao ◽

Leanne P. Kelley ◽

...

Keyword(s):

Receptor Antagonist ◽

Pharmacological Characterization ◽

Thromboxane Synthase ◽

Thromboxane Receptor ◽

Thromboxane Synthase Inhibitor ◽

Thromboxane Receptor Antagonist ◽

Synthase Inhibitor

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The dual thromboxane receptor antagonist and thromboxane synthase inhibitor EV-077 is a more potent inhibitor of platelet function than aspirin

Journal of Thrombosis and Haemostasis ◽

10.1111/j.1538-7836.2011.04446.x ◽

2011 ◽

Vol 9 (10) ◽

pp. 2109-2111 ◽

Author(s):

P. FONTANA ◽

P. ALBERTS ◽

K. S. SAKARIASSEN ◽

H. BOUNAMEAUX ◽

J.-P. MEYER ◽

...

Keyword(s):

Receptor Antagonist ◽

Platelet Function ◽

Potent Inhibitor ◽

Thromboxane Synthase ◽

Thromboxane Receptor ◽

Thromboxane Synthase Inhibitor ◽

Thromboxane Receptor Antagonist ◽

Synthase Inhibitor

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Basic pharmacophore of some antithrombotic agents with combined thromboxane receptor antagonist (TxRA)/thromboxane synthase inhibitor (TxSI) activity

Drug Development Research ◽

10.1002/(sici)1098-2299(199610)39:2<197::aid-ddr14>3.0.co;2-9 ◽

1996 ◽

Vol 39 (2) ◽

pp. 197-200 ◽

Author(s):

Yang Jie ◽

Hua Weiyi

Keyword(s):

Receptor Antagonist ◽

Antithrombotic Agents ◽

Thromboxane Synthase ◽

Thromboxane Receptor ◽

Thromboxane Synthase Inhibitor ◽

Thromboxane Receptor Antagonist ◽

Synthase Inhibitor

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Effects of a thromboxane receptor antagonist (NT-126) and a thromboxane synthase inhibitor (OKY-O46) on protamine-induced circulatory changes in dogs

Journal of Cardiothoracic and Vascular Anesthesia ◽

10.1053/jcan.2000.18449 ◽

2000 ◽

Vol 14 (6) ◽

pp. 687-692 ◽

Author(s):

Taro Mizutani ◽

Shinji Takahashi ◽

Shin-ichi Kihara ◽

Hidenori Toyooka

Keyword(s):

Receptor Antagonist ◽

Thromboxane Synthase ◽

Thromboxane Receptor ◽

Thromboxane Synthase Inhibitor ◽

Thromboxane Receptor Antagonist ◽

Synthase Inhibitor

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Changes in plasma and urinary 11-dehydrothromboxane B2 in healthy subjects produced by oral CS-518, a novel thromboxane synthase inhibitor

European Journal of Clinical Pharmacology ◽

10.1007/bf00315398 ◽

1993 ◽

Vol 45 (3) ◽

pp. 283-286 ◽

Author(s):

T. Uematsu ◽

W. Takasaki ◽

K. Kosuge ◽

K. Wada ◽

H. Matsuno ◽

...

Keyword(s):

Healthy Subjects ◽

Thromboxane Synthase ◽

Thromboxane Synthase Inhibitor ◽

Synthase Inhibitor

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Effects of CS-518, a thromboxane synthase inhibitor, on eosinophil function

European Journal of Pharmacology ◽

10.1016/0014-2999(93)90989-u ◽

1993 ◽

Vol 239 (1-3) ◽

pp. 159-169 ◽

Author(s):

Kazuhiro Itoh ◽

Osamu Mukaiyama ◽

Yumiko Satoh ◽

Takeshi Yamaguchi ◽

Yoshio Iizuka

Keyword(s):

Thromboxane Synthase ◽

Thromboxane Synthase Inhibitor ◽

Synthase Inhibitor

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FCE 24265: A combined calcium-channel blocker and thromboxane synthase inhibitor

Pharmacological Research ◽

10.1016/s1043-6618(09)80487-8 ◽

1990 ◽

Vol 22 ◽

pp. 485

Author(s):

F. Vaghi ◽

M. Grossoni ◽

C. Ferti ◽

P. Salvati

Keyword(s):

Calcium Channel ◽

Calcium Channel Blocker ◽

Channel Blocker ◽

Thromboxane Synthase ◽

Thromboxane Synthase Inhibitor ◽

Synthase Inhibitor

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G 619, a Dual Thromboxane Synthase Inhibitor and Thromboxane A2 Receptor Antagonist, Reduces Myocardial Damage and Polymorpho-nuclear Leukocyte Accumulation following Coronary Artery Occlusion and Reperfusion in Rats

Pharmacology ◽

10.1159/000139094 ◽

1993 ◽

Vol 47 (3) ◽

pp. 167-175 ◽

Author(s):

Francesco Squadrito ◽

Mariapatrizia Ioculano ◽

Domenica Altavilla ◽

Basilia Zingarelli ◽

Patrizia Canale ◽

...

Keyword(s):

Coronary Artery ◽

Receptor Antagonist ◽

Myocardial Damage ◽

Coronary Artery Occlusion ◽

Artery Occlusion ◽

Thromboxane Synthase ◽

Leukocyte Accumulation ◽

Thromboxane Synthase Inhibitor ◽

Synthase Inhibitor

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