Lovastatin treatment decreases mononuclear cell infiltration into the CNS of Lewis rats with experimental allergic encephalomyelitis

2001 ◽  
Vol 66 (2) ◽  
pp. 155-162 ◽  
Author(s):  
Romesh Stanislaus ◽  
Avtar K. Singh ◽  
Inderjit Singh
Keyword(s):  
Mononuclear Cell ◽  
Experimental Allergic Encephalomyelitis ◽  
Cell Infiltration ◽  
Mononuclear Cell Infiltration ◽  
Allergic Encephalomyelitis ◽  
Lewis Rats ◽  
Experimental Allergic ◽  
Lovastatin Treatment

Sodium fusidate (fusidin) ameliorates the course of monophasic experimental allergic encephalomyelitis in the Lewis rat

2001 ◽  
Vol 7 (2) ◽  
pp. 101-104 ◽  
Author(s):  
Roberto Di Marco ◽  
Gaetano Puglisi ◽  
Gianpaolo Papaccio ◽  
Alessandra Nicoletti ◽  
Francesco Patti ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Mononuclear Cell ◽  
Experimental Allergic Encephalomyelitis ◽  
Prophylactic Treatment ◽  
Lewis Rat ◽  
Mononuclear Cell Infiltration ◽  
Allergic Encephalomyelitis ◽  
Delayed Onset ◽  
Experimental Allergic ◽  
Inflammatory Effect

We have evaluated the effect of the immunosuppressant sodium fusidate (fusidin) on the course of acute monophasic experimental encephalomyelitis (EAE) in male Lewis rats. Prophylactic treatment with fusidin, 80 or 120 mg/kg bd wt., markedly ameliorated the course of the disease in rats immunized with myelin basic proteins in complete Freund's adjuvant, entailing delayed onset of symptoms, lower clinical scores and more rapid recovery than PBS-treated control rats. The fusidin-treated, immunized rats exhibited milder mononuclear cell infiltration of brains and spinal cords than control animals. These data provide further evidence for the anti-inflammatory effect of fusidin and suggest that this drug may be valuable for the treatment of human multiple sclerosis.

Amelioration of experimental allergic encephalomyelitis in Lewis rats by lovastatin

1999 ◽  
Vol 269 (2) ◽  
pp. 71-74 ◽  
Author(s):  
Romesh Stanislaus ◽  
Kalipada Pahan ◽  
Avtar K. Singh ◽  
Inderjit Singh
Keyword(s):  
Experimental Allergic Encephalomyelitis ◽  
Allergic Encephalomyelitis ◽  
Lewis Rats ◽  
Experimental Allergic

scholarly journals Transfer of experimental allergic encephalomyelitis in Lewis rats using supernates of incubated sensitized lymph node cells.

1977 ◽  
Vol 145 (5) ◽  
pp. 1405-1410 ◽  
Author(s):  
C C Whitacre ◽  
P Y Paterson
Keyword(s):  
Spinal Cord ◽  
Lymph Node ◽  
Guinea Pig ◽  
Experimental Allergic Encephalomyelitis ◽  
Nervous Tissue ◽  
Allergic Encephalomyelitis ◽  
Lewis Rats ◽  
Transfer Activity ◽  
Lymph Node Cells ◽  
Experimental Allergic

Supernates derived from incubated lymph node cells of Lewis rats sensitized to guinea pig spinal cord-Freund's adjuvant transfer experimental allergic encephalomyelitis (EAE) to syngeneic recipients. EAE supernatant transfer activity (EAE-STA) is not demonstrable in supernates derived from LNC of control donors not sensitized to nervous tissue. After addition of brain antigen to active supernates, EAE-STA is not longer demonstrable.

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